Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions
First Claim
1. A method for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile, comprising:
- a) performing at least one time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent measurement profile;
b) defining a set of a plurality of predictor variables which sufficiently define the data of the time-dependent measurement profile;
c) deriving a model that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables; and
d) utilizing the model of step c) to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample;
wherein said set of predictor variables includes a plurality of;
a minimum of the first derivative of the profile, a time index of the minimum of the first derivative, a minimum of the second derivative of the profile, a time index of the minimum of the second derivative, a maximum of the second derivative of the profile, a time index of the maximum of the second derivative, an overall change in the coagulation parameter during the time-dependent measurement on the unknown sample, a clotting time, a slope of the profile prior to clot formation, and a slope of the profile after clot formation.
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Abstract
A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.
24 Citations
38 Claims
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1. A method for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile, comprising:
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a) performing at least one time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent measurement profile; b) defining a set of a plurality of predictor variables which sufficiently define the data of the time-dependent measurement profile; c) deriving a model that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables; and d) utilizing the model of step c) to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample; wherein said set of predictor variables includes a plurality of;
a minimum of the first derivative of the profile, a time index of the minimum of the first derivative, a minimum of the second derivative of the profile, a time index of the minimum of the second derivative, a maximum of the second derivative of the profile, a time index of the maximum of the second derivative, an overall change in the coagulation parameter during the time-dependent measurement on the unknown sample, a clotting time, a slope of the profile prior to clot formation, and a slope of the profile after clot formation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An apparatus for performing at least one time-dependent measurement on an unknown sample to derive at least one time-dependent measurement profile, and predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from the at least one time-dependent measurement profile, comprising:
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means for performing at least one time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent measurement profile; means for defining a set of a plurality of predictor variables which sufficiently define the data of the time-dependent measurement profile; means for deriving a model that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables; and means for utilizing the model of step c) to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample; wherein said set of predictor variables includes a plurality of;
a minimum of the first derivative of the profile, a time index of the minimum of the first derivative, a minimum of the second derivative of the profile, a time index of the minimum of the second derivative, a maximum of the second derivative of the profile, a time index of the maximum of the second derivative, an overall change in the coagulation parameter during the time-dependent measurement on the unknown sample, a clotting time, a slope of the profile prior to clot information, and a slope of the profile after clot formation. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification