Silastic and polymer-based catheters with improved antimicrobial/antifungal properties

• US 5,709,672 A
• Filed: 11/01/1995
• Issued: 01/20/1998
• Est. Priority Date: 11/01/1995
• Status: Expired due to Fees

• Current Assignee: Texas Tech University Health Sciences Center (Texas Tech University System)
• Original Assignee: Texas Tech University Health Sciences Center (Texas Tech University System)
• Inventors: Illner, Hana
• Primary Examiner(s): DUDASH, DIANA L
• Application Number:
  US08/551,544
• Time in Patent Office: 811 Days
• Field of Search: 2/161.7, 604/265, 424/404, 424/423, 424/430, 427/2.3
• US Class Current: 604/265
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

Disclosed are devices having improved anti-microbial resistance to bacteria and fungus. Indwelling devices, such as catheters and the like, include low amounts of gentian violet, or a combination of gentian violet and silver nitrate. Methods for preparing the treated devices using alcohol and similar solvents are also detailed. The devices may be made of polyurethane, silicone, or other similarly absorptive material. Methods of inhibiting infection and long-term catheter management with the described devices are also disclosed.

Claims

1. A medical device comprising silicone having a surface that includes an antimicrobially and antifungally effective amount of gentian violet of about 0.01% to about 0.05% by weight.

2. The medical device of claim 1 further defined as a catheter.

3. A medical device comprising silicone having a surface that includes an amount of gentian violet of about 0.01% to about 0.1% by weight, wherein said silicone further comprises an antimicrobially effective amount of silver nitrate.

4. The medical device of claim 3 wherein the amount of gentian violet is about 0.01% by weight.

5. The medical device of claim 3 wherein the amount of silver nitrate is about 0.1% by weight to about 2.0% by weight.

6. A medical device comprising polyurethane having a surface comprising an antimicrobially and antifungally effective amount of gentian violet of about 0.01% by weight to about 0.05% by weight.

7. The medical device of claim 6 wherein the amount of gentian violet is about 0.01% by weight.

8. The medical device of claim 6 further defined as catheter.

9. A medical device comprising polyurethane having a surface that includes an amount of gentian violet of about 0.01% to about 0.1% by weight, wherein said polyurethane is further defined as comprising an antimicrobially effective amount of silver nitrate.

10. The medical device of claim 9 wherein the amount of silver nitrate is about 0.1% by weight to about 2.0% by weight.