Iontophoretic drug delivery

• US 5,711,761 A
• Filed: 02/24/1995
• Issued: 01/27/1998
• Est. Priority Date: 10/29/1984
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Untereker, Darrel F., Phipps, Joseph B., Lattin, Gary A.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/394,075
• Time in Patent Office: 1,068 Days
• Field of Search: 604/20, 607/115, 607/149, 607/152, 607/153
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.

Claims

1. An electrotransport method of delivering an ionic drug D+ comprising the steps of:

providing a reservoir comprising DOH dispersed in a polymer gel in electrical communication with an electrochemically active conductive member;

contacting said reservoir to the skin of a patient;

hydrolyzing water in said reservoir producing hydronium ions;

reacting the hydronium ions with the DOH producing an ionic drug, D+; and

,

electrically transporting D+ through the skin.

2. The method of claim 1 wherein the DOH is lithium hydroxide.

5. The method of claims 1 or 3 wherein the electrochemically active conductive member is also sacrificial.

6. The method of claims 1 or 3 wherein the electrochemically active conductive member is an electrode constructed from a material selected from the group consisting of stainless steel and platinum.

3. An electrotransport method of delivering an ionic drug D- comprising the steps of:

providing a reservoir comprising HD dispersed in a polymer gel in electrical communication with an electrochemically active conductive member;

contacting said reservoir to the skin of a patient;

reducing water in said reservoir producing hydroxyl ions;

reacting the hydroxyl ions with the HD producing an ionic drug, D-; and

,

electrically transporting D- through the skin.

4. The method of claim 3 wherein the HD is salicylic acid.

7. A method for delivering an ionic drug D-, comprising the steps of:

providing an electrochemically active conductive member in electrical communication with a reservoir containing the ionic drug D- compounded in its acidic form HD, wherein the ionic drug D- is permeable through a reservoir membrane;

contacting the reservoir to the skin of a patient; and

applying a negative voltage to said conductive member to reduce water in the reservoir producing hydroxyl ions which react with the acidic form HD of the ionic drug producing water and driving the ionic drug D- through the skin of a patient.

8. The method of claim 7 wherein the electrochemically active conductive member is also sacrificial.

9. The method of claim 7 wherein the electrochemically active conductive member is an electrode constructed from a material selected from the group consisting of stainless steel and platinum.