Device for monitoring changes in analyte concentration

• US 5,711,861 A
• Filed: 11/22/1995
• Issued: 01/27/1998
• Est. Priority Date: 11/22/1995
• Status: Expired due to Term

• Current Assignee: Legacy Good Samaritan Hospital And Medical Center
• Original Assignee: Eric S. Wilgus, Ward W. Kenneth
• Inventors: Ward, W. Kenneth, Wilgus, Eric S.
• Primary Examiner(s): Bell, Bruce F.
• Application Number:
  US08/561,972
• Time in Patent Office: 797 Days
• Field of Search: 204/415, 204/403, 422/68.1, 422/82.03, 422/82.01, 435/288, 435/291, 435/817, 128/635, 128/642
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

The invention provides an electrochemical sensor system for measuring analyte concentrations in a sample fluid. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped body containing multiple anodes on opposing sides of the body. Electrodes are connected to a transmitter which transmits radio signals to an external receiver and computer where data is processed to yield relative glucose concentration figures.

Claims

1. A device for electrochemically sensing changes in the concentration of an analyte of interest comprising

an implantable sensor body having a pair of spaced facial expanses, each expanse of the body having at least one analyte-sensing electrode pair including an anode and a cathode spaced apart from each other and covered by a membrane which is semi-permeable to the analyte of interest, and

an enzyme composition covering each anode of each analyte-sensing electrode pair, wherein the enzyme composition reacts specifically with the analyte of interest.

2. The device of claim 1 wherein the analyte of interest is glucose.

3. The device of claim 2 wherein the enzyme composition includes glucose oxidase and is located between the anode and the membrane.

4. The device of claim 3 wherein each expanse of the sensor body has an interferent retarding layer between the anode and the enzyme layer.

5. The device of claim 1 wherein the membrane comprises polyparaxylxylene.

6. The device of claim 1 wherein each expanse of the sensor body includes a plurality of anodes.

7. The device of claim 6 wherein each expanse of the sensor body has a plurality of electrode pairs, each electrode pair including one anode and one cathode.

8. The device of claim 7 wherein each expanse of the sensor body has four electrode pairs.

9. The device of claim 8 wherein the sensor body is disk-shaped.

10. A device for electrochemically sensing changes in the concentration of an analyte of interest comprising

an implantable sensor body including a plurality of analyte-sensing electrode pairs, each electrode pair including an anode and a cathode, and

a membrane comprising polyparaxylxylene or a carbonate-based polyurethane coveting the anodes.

11. The device of claim 10 further comprising a layer including glucose oxidase disposed between the anode and the membrane, wherein the device senses changes in glucose concentration of a fluid surrounding the device.

12. The device of claim 10 wherein the sensor body has two opposing sides, each side of the sensor body having at least one anode and at least one cathode.

13. The device of claim 12 wherein each side of the sensor body has a plurality of anodes.

14. The device of claim 13 wherein each side of the sensor body has a plurality of cathodes, each cathode being paired with one of the anodes.

15. A device for electrochemically sensing the concentration of an analyte of interest comprising

an implantable sensor body supporting and defining multiple analyte detection sites, each site having an analyte-sensing electrode pair, each electrode pair including an anode and a cathode for generating signals indicative of analyte concentration at one of the sites on the sensor body.

16. The device of claim 15 wherein the sensor body has two opposing sides, the electrode pairs being distributed on both sides of the sensor body.

17. The device of claim 16 wherein the sensor body is disk-shaped.

18. The device of claim 16 wherein each side of the sensor body has at least four electrode pairs.

19. The device of claim 15 wherein the anodes lead to a common anode conductor and the cathodes lead to a common cathode conductor.

20. The device of claim 15 wherein the analyte of interest is glucose and each anode is covered with an enzyme layer comprising glucose oxidase.

21. The device of claim 15 wherein the sensor body has multiple sides, each side having an analyte detection site.

22. A device for electrochemically sensing the concentration of an analyte of interest comprising

an implantable disk-shaped sensor body having two opposing facial expanses, each facial expanse containing at least one analyte detection site including an anode and a cathode covered by a membrane which is semi-permeable to the analyte of interest.