Oral composition

• US 5,711,937 A
• Filed: 12/27/1995
• Issued: 01/27/1998
• Est. Priority Date: 06/28/1993
• Status: Expired due to Fees

• Current Assignee: Lion Corporation
• Original Assignee: Lion Corporation
• Inventors: Harada, Yoshihiro, Morishima, Midori, Ohta, Maimi, Gomi, Tetsuo, Nishida, Yasukuni
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US08/571,914
• Time in Patent Office: 762 Days
• Field of Search: 424/49-58
• US Class Current: 424/49
• CPC Class Codes: A61K 8/33 containing oxygen
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

An oral composition is provided which is improved in antibody stability so that the antibody may satisfactorily exert its effect after long-term storage and has a pleasant feel on use. A flavor component selected from the group consisting of carvone, anethole, cineole, methyl salicylate, eugenol, ethyl butyrate, and cinnamic aldehyde, and l-menthol are blended in a weight ratio of from 1:9 to 8:2 in an oral composition containing an antibody selected from the group consisting of a serum antibody, egg yolk antibody and milk antibody.

Claims

1. An oral composition characterized in that a flavor component selected from the group consisting of cineole, methyl salicylate, ethyl butyrate, and cinnamic aldehyde, and l-menthol are blended in a weight ratio of from 1:

9 to 8;

2 in an oral composition containing an antibody selected from the group consisting of a serum antibody, egg yolk antibody and milk antibody.

2. The oral composition of claim 1 wherein said antibody is an antibody specific for dental cariogenic bacteria.

3. The oral composition of claim 2 wherein said cariogenic bacteria is Streptococcus mutans.

4. The oral composition of claim 1 wherein said antibody is an antibody specific for periodontal disease associated bacteria.

5. The oral composition of claim 4 wherein said periodontal disease associated bacteria is selected from the group consisting of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Actinomyces viscosus, Prevotella intermedia, Fusobacterium nucleatum, species of Capnocytophaga, Campylobacter rectus, Bacteroides forsythus, and Spirochaeta such as Treponema denticola.

6. An oral composition according to claim 1, wherein the flavor component and the l-menthol are blended in a weight ratio of from 2:

8 to 7;

3.

7. An oral composition according to claim 1, wherein the flavor component is cineole.

8. An oral composition according to claim 1, wherein the flavor component is methyl salicylate.

9. An oral composition according to claim 1, wherein the flavor component is ethyl butyrate.

10. An oral composition according to claim 1, wherein the flavor component is cinnamic aldehyde.