Methods for reducing or eliminating post-surgical adhesion formation
First Claim
1. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks, where A is an aliphatic polyester and B is a polyoxyalkylene polymer unit, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
7 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition comprising chain-extended poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
-
Citations
45 Claims
- 1. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks, where A is an aliphatic polyester and B is a polyoxyalkylene polymer unit, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
-
11. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure:
- ##STR5## where m, a and b are positive integers, R is an ethylene group and/or propylene group with the proviso that R is not exclusively a propylene group when m is more than 1, R'"'"' is a C2 to C8 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'"'"'-diphenylmethane, toluene, naphthalene, 4,4'"'"'-dicyclohexylmethane, cyclohexyl, 3,3'"'"'-dimethylphenyl, 3,3'"'"'-dimethyl-diphenylmethane, 4,6'"'"'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene and R1 is H or CH3, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
- View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 43)
-
19. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure:
- ##STR6## where m, x and y are positive integers, R is an ethylene and/or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R1 is a hydrogen or methyl group, R" is a C0 to C12 alkylene group or a hydroxyl or carboxylic acid substituted alkyl group, a cycloalkyl, a hydroxyl-containing cyclo alkyl, or cycloalkyl-containing group, an aryl or aryl-containing group, or a polyoxyalkylene chain comprised of poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
- View Dependent Claims (20, 21, 22, 23, 24, 25, 44)
-
26. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure:
- ##STR7## where j, k and m are positive integers, R is an ethylene or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R'"'"' is a C2 to C12 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'"'"'-diphenylmethane, toluene, naphthalene, 4,4'"'"'-dicyclohexylmethane, cyclohexyl, 3,3'"'"'-dimethylphenyl, 3,3'"'"'-dimethyl-diphenylmethane, 4,6'"'"'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene, R'"'"'" is a polyoxyalkylene chain comprising poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide) and R1 is H or CH3, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
- View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 45)
- 36. A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/polyethylene oxide ABA triblocks, where said A block comprises an aliphatic polyester and said B block comprises poly(ethyleneoxide) or poly(ethyleneoxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Specification