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Chimeric receptor molecules for delivery of co-stimulatory signals

  • US 5,712,149 A
  • Filed: 02/03/1995
  • Issued: 01/27/1998
  • Est. Priority Date: 02/03/1995
  • Status: Expired due to Term
First Claim
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1. A DNA encoding a chimeric membrane-bound protein, said protein comprising in the N-terminal to C-terminal direction:

  • a signal sequence;

    an extracellular binding domain of a surface membrane or secreted protein that binds specifically to at least one ligand;

    a transmembrane domain; and

    a cytoplasmic domain of CD2 or CD28;

    wherein said extracellular domain is not obtained from CD2 or CD28, and when said DNA is placed in a selected host cell under conditions suitable for expression, said chimeric membrane-bound protein is expressed and co-stimulates effector function signaling in said host cell upon binding of a ligand to the extracellular domain.

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