Catheter with fluid medication injectors

• US 5,713,863 A
• Filed: 01/11/1996
• Issued: 02/03/1998
• Est. Priority Date: 01/11/1996
• Status: Expired due to Term

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Interventional Technologies Incorporated (Boston Scientific Corporation)
• Inventors: Barath, Peter I., Vigil, Dennis M.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): Mehta, Bhisma
• Application Number:
  US08/584,310
• Time in Patent Office: 754 Days
• Field of Search: 604/19, 604/22, 604/48-50, 604/52, 604/53, 604/93, 604/104-9, 604/181, 604/183, 604/264, 606/191, 606/198
• US Class Current: 604/104
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

A device for injecting medication into a vessel wall includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. A plurality of injectors are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the injectors into the vessel wall. A fluid medication is then introduced through the multi-lumen catheter, into the flexible tubes and out of the injectors for infusion into the vessel wall.

Claims

1. A device useful for infusing a medicament into an arterial wall which comprises:

a catheter defining a longitudinal axis;

a grommet disposed about said longitudinal axis;

a plurality of resilient tubes, each said tube formed with a tube lumen and having a proximal end, a distal end, and a central region, said proximal end of each said tube being attached to said catheter and said distal end of each said tube being attached to said grommet;

at least one hollow injector attached to and projecting away from said central region of each said tube, said hollow injector being in fluid communication with said tube lumen;

means for moving said grommet along said longitudinal axis between a first position wherein said central region of each said tube is held substantially juxtaposed to said longitudinal axis with said injector projecting away from each said tubes and a second position wherein said central region of each said tube is radially distanced from said longitudinal axis to urge said hollow injector into an arterial wall; and

means in fluid communication with each said tube lumen adapted for injecting a medicament into each said tube lumen and through said injectors.

2. A device as recited in claim 1 wherein said injectors comprise:

a base; and

a hollow protrusion having a first end and a second end, said protrusion projecting from said base to establish a fluid channel through said base and through said protrusion, said first end of said protrusion being affixed to said base and said second end formed with a cutting edge.

3. A device as recited in claim 2 wherein said protrusions are substantially cylindrical in shape.

4. A device as recited in claim 2 wherein said protrusions are substantially conical in shape.

5. A device as recited in claim 1 wherein said catheter is formed with at least one catheter lumen.

6. A device as recited in claim 5 wherein one said catheter lumen is attached in fluid communication with each said tube lumen.

7. A device as recited in claim 5 wherein one said catheter lumen is dimensioned to receive a guidewire therethrough and positioning said device.

8. A device as recited in claim 7 wherein said means for moving said grommet comprises a push-pull wire, said push-pull wire being attached to said grommet and extending through one said catheter lumen.

9. A device useful for infusing a medicament into an arterial wall which comprises:

a catheter defining a longitudinal axis;

a grommet disposed about said longitudinal axis;

a plurality of resilient tubes, each said tube having a proximal end, a distal end, and a central region, said proximal end of each said tube being attached to said catheter, said distal end of each said tube attached to said grommet;

at least one injector attached to and projecting away from said central region of each said tube;

means for moving said central region of each said tube between a first position wherein said central region is held substantially juxtaposed to said longitudinal axis with said injector projecting away from each said tube and a second position wherein said central region is radially distanced from the longitudinal axis to urge said hollow injector into an arterial wall; and

pumping means in fluid communication with each said injector which is adapted for injecting a medicament through the injectors.

10. A device as recited in claim 9 wherein said injectors comprise:

a base; and

a hollow protrusion having a first end and a second end, said protrusion projecting from said base to establish a fluid channel through said base and through said protrusion, said first end of said protrusion being affixed to said base and said second end formed with a cutting edge.

11. A device as recited in claim 10 wherein said protrusions are substantially cylindrical in shape.

12. A device as recited in claim 10 wherein said protrusions are substantially conical in shape.

13. A device as recited in claim 10 wherein said catheter is formed with at least one catheter lumen.

14. A device as recited in claim 13 wherein one said catheter lumen is attached in fluid communication with said tube.

15. A device as recited in claim 13 wherein one said catheter lumen is dimensioned to receive a guidewire therethrough for guiding and position said device.

16. A device as recited in claim 15 wherein said means for moving said central region of each said tube comprises a push-pull wire, said push-pull wire attached to said grommet and extending through one said lumen of said catheter.

17. A method for infusing a medicament into an arterial wall which comprises the steps of:

advancing a device through the vessel, said device comprising a catheter defining a longitudinal axis, a grommet disposed about said longitudinal axis, a plurality of resilient tubes, each said tube having a proximal end, a distal end, and a central region, said proximal end of each said tube being attached to said catheter, said distal end of each said tube attached to said grommet, at least one hollow injector attached to and projecting away from said central region of each said tube, a push-pull wire for moving said central region of each said tube between a first position wherein said central region is held substantially juxtaposed to said longitudinal axis with said injector projecting away from each said tube and a second position wherein said central region is radially distanced from said longitudinal axis to urge said hollow injector into the arterial wall, and means in fluid communication with each said hollow injector for injecting a medicament through said hollow injectors into the arterial wall;

selectively withdrawing said push-pull wire to move said central region of each said tube to said second position to urge said hollow injectors into the arterial wall; and

selectively activating said pumping means to pass a medicament through said injectors to infuse the vessel wall.

18. A method as recited in claim 17 further comprising the steps of:

prepositioning a guidewire in the vessel;

positioning a catheter lumen of the device over a portion of the guidewire; and

advancing said device over said guidewire.