Defibrillation threshold reduction system

• US 5,713,924 A
• Filed: 06/27/1995
• Issued: 02/03/1998
• Est. Priority Date: 06/27/1995
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Min, Xiaoyi, Hill, Michael R. S., Mongeon, Luc R.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/495,251
• Time in Patent Office: 952 Days
• Field of Search: 607/4, 607/5, 607/14
• US Class Current: 607/4
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.

Claims

1. A device for providing a combined defibrillation therapy, comprising:

pacing electrode means for delivering pacing energy pulse bursts to a first chamber of a patient'"'"'s heart;

defibrillation electrode means for delivering high energy pulses to said first chamber of said heart;

means for detecting fibrillation in said first chamber of said heart;

means for triggering delivery of said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart;

pacing pulse generator means responsive to said triggering means for delivering pacing energy pulse bursts having a frequency of 20 Hz or greater to said pacing electrode means;

defibrillation pulse generator means responsive to said triggering means for generating said high energy pulses for delivering a high energy pulse to said defibrillation electrode means in conjunction with each delivery of a said pulse burst to said pacing electrode means.

2. The device of claim 1, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses during delivery of said pulse bursts.

3. The device of claim 1, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses on termination of said pulse bursts.

4. The device of claim 1, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses after a delay following termination of said pulse bursts.

5. A device according to claim 2 or claim 3 or claim 4 further comprising means for sensing depolarizations of a second chamber of said heart and wherein said control means comprises means for delivering said high energy pulses synchronized to detected depolarizations of said second chamber of said heart.

6. A device according to claim 2 or claim 3 or claim 4 wherein said pacing pulse generator means comprises means for delivering pacing energy pulse bursts having a frequency of about 50-200 Hz to said pacing electrode means.

7. A method of providing a combined defibrillation therapy, comprising:

locating a pacing electrode in contact with a first chamber of a patient'"'"'s heart;

locating defibrillation electrodes proximate said first chamber of said heart;

detecting fibrillation in said first chamber of said heart;

delivering said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart, said combined therapy delivering step in turn comprising;

delivering pacing energy pulse bursts having a frequency of 20 Hz or greater to said pacing electrode and delivering a high energy pulse to said defibrillation electrodes in conjunction with each delivery of said pulse bursts to said pacing electrode.

8. The method of claim 7, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses during delivery of said pulse bursts.

9. The method of claim 7, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses on terminations of said pulse bursts.

10. The method of claim 7, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses after a delay following terminations of said pulse bursts.

11. A method according to claim 8 or claim 9 or claim 10 further comprising sensing depolarizations of a second chamber of said heart and wherein step of delivering said high energy pulses comprises delivering said high energy pulses synchronized to detected depolarizations of said second chamber of said heart. first chamber which is exhibits a relatively lower current density than other portions of said first chamber, during delivery of said high energy pulses.

12. A method according to claim 8 or claim 9 or claim 10 wherein said step of locating said pacing electrode comprises locating said pacing electrode in a region of said first chamber which exhibits a relatively lower current density than other portions of said first chamber, during delivery of said high energy pulses.

13. A method according to claim 8 or claim 9 or claim 10 wherein said step of delivering said pulse bursts comprises delivering pulse bursts having a frequency of 50-200 Hz.

14. A method of providing a combined defibrillation therapy, comprising:

locating defibrillation electrodes proximate said first chamber of said heart;

locating a pacing electrode in contact with a first chamber of a patient'"'"'s heart;

detecting fibrillation in said first chamber of said heart;

delivering said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart, said combined therapy delivering step in turn comprising;

delivering pacing energy pulse bursts to said pacing electrode and delivering a high energy pulse to said defibrillation electrodes in conjunction with each delivery of said pulse bursts to said pacing electrode;

wherein said step of locating said pacing electrode comprises locating said pacing electrode in a region of said first chamber which exhibits a relatively lower current density than other portions of said first chamber, during delivery of said high energy pulses.

16. The method of claim 14 or claim 15, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses during delivery of said pulse bursts.

17. The method of claim 14 or claim 15, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses on terminations of said pulse bursts.

18. The method of claim 14 or claim 15, wherein said step of delivering said high energy pulses comprises initiating delivery of said high energy pulses after a delay following terminations of said pulse bursts.

15. A method of providing a combined defibrillation therapy, comprising:

locating defibrillation electrodes proximate a first chamber of said heart;

locating a pacing electrode in contact with said first chamber of a patient'"'"'s heart;

detecting fibrillation in said first chamber of said heart;

sensing depolarizations of a second chamber of said heart;

delivering said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart, said combined therapy delivering step in turn comprising;

delivering pacing energy pulse bursts to said pacing electrode and delivering a high energy pulse to said defibrillation electrodes, synchronized to detected depolarizations of said second chamber of said heart in conjunction with delivery of said pulse bursts to said pacing electrode.

19. A method of providing a combined defibrillation therapy, comprising:

locating defibrillation electrodes proximate a first chamber of said heart;

locating a pacing electrode in contact with a first chamber of a patient'"'"'s heart;

detecting fibrillation in said first chamber of said heart;

sensing depolarizations of a second chamber of said heart;

delivering said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart, said combined therapy delivering step in turn comprising;

delivering pacing energy pulse bursts to said pacing electrode and delivering high energy pulses to said defibrillation electrodes during delivery of said pulse bursts to said pacing electrode.

20. A device for providing a combined defibrillation therapy, comprising:

pacing electrode means for delivering pacing energy pulse bursts to a first chamber of a patient'"'"'s heart;

defibrillation electrode means for delivering high energy pulses to said first chamber of said heart;

means for detecting fibrillation in said first chamber of said heart;

means for sensing depolarizations of a second chamber of said heart;

means for triggering delivery of said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart;

pacing pulse generator means responsive to said triggering means for delivering pacing energy pulse bursts to said pacing electrode means;

defibrillation pulse generator means responsive to said triggering means for generating said high energy pulses for delivering a high energy pulse to said defibrillation electrode means in conjunction with delivery of a said pulse burst to said pacing electrode means, synchronized to a detected depolarization of said second chamber of said heart.

21. The device of claim 20, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses during delivery of said pulse bursts.

22. The device of claim 20, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses on termination of said pulse bursts.

23. The device of claim 20, wherein said triggering means comprises control means for controlling the timing of said pulse bursts and said high energy pulses, said control means comprising:

means for initiating delivery of said high energy pulses after a delay following termination of said pulse bursts.

24. A device for providing a combined defibrillation therapy, comprising:

pacing electrode means for delivering pacing energy pulse bursts to a first chamber of a patient'"'"'s heart;

defibrillation electrode means for delivering high energy pulses to said first chamber of said heart;

means for detecting fibrillation in said first chamber of said heart;

means for triggering delivery of said combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart;

pacing pulse generator means responsive to said triggering means for delivering pacing energy pulse bursts to said pacing electrode means;

defibrillation pulse generator means responsive to said triggering means for generating said high energy pulses for delivering high energy pulses to said defibrillation electrode means during delivery of said pulse bursts to said pacing electrode means.

29. A device according to any of claims 24, 25, 26 or 27, further comprising:

means for sensing depolarizations of a second chamber of said heart; and

wherein said means for triggering said defibrillation pulse generator means comprises means for triggering said defibrillation pulse generator means to deliver high energy pulses to said chamber of said heart means in response to a sensed depolarization of said second chamber of said heart, after said high voltage capacitor is charged.

25. A device for providing a combined defibrillation therapy, comprising:

pacing pulse generator means for generating pacing pulses;

pacing electrode means coupled to said pacing pulse generator means for delivering said pacing pulses to a first chamber of a patient'"'"'s heart;

defibrillation pulse generator means for generating high energy pulses;

defibrillation electrode coupled to said defibrillation pulse generator means, for delivering said high energy pulses to said first chamber of said heart;

means for activating said pacing pulse generator means to deliver pacing pulses to said first chamber of said heart in an anti-bradycardia pacing mode;

means for detecting fibrillation in said first chamber of said heart;

means for triggering delivery of a combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart;

comprising means for triggering said pacing pulse generator means to deliver a pulse burst to said chamber of said heart and means for triggering said defibrillation pulse generator means to deliver a high energy pulse to said chamber of said heart in conjunction with delivery of said pulse burst to said chamber of said heart.

26. A device for providing a combined pacing and defibrillation therapy, comprising:

pacing pulse generator means for generating pacing pulses;

pacing electrode means coupled to said pacing pulse generator means for delivering said pacing pulses to a first chamber of a patient'"'"'s heart;

defibrillation pulse generator means for generating high energy pulses, said defibrillation pulse generator comprising a high voltage output capacitor;

defibrillation electrode means coupled to said defibrillation pulse generator means, for delivering said high energy pulses to said first chamber of said heart;

means for detecting fibrillation in said first chamber of said heart;

means for triggering delivery of a combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart;

comprising means for initiating charging of said high voltage output capacitor, means for defining a first time interval which will expire after charging of said high voltage capacitor, means for triggering said pacing pulse generator means to deliver pulse bursts to said chamber of said heart commencing on the beginning of said first time interval and continuing until said high voltage capacitor is charged and means for triggering said defibrillation pulse generator means to deliver high energy pulses to said chamber of said heart means in response to said high voltage capacitor being charged.

27. A device according to claim 26 wherein said means for triggering said pacing pulse generator comprises means for terminating delivery of said pulse bursts on expirations of said first time intervals.

28. A device according to claim 26 wherein said means for triggering said pacing pulse generator comprises means for terminating delivery of said pulse bursts on deliveries of said high energy pulses.

30. A method of providing a combined pacing and defibrillation therapy, comprising:

employing a pacing pulse generator to deliver pacing pulses to a first chamber of a heart in an anti-bradycardia pacing mode;

detecting fibrillation in said first chamber of said heart;

delivering a combined defibrillation therapy, in response to detection of fibrillation in said first chamber of said heart, by employing said pacing pulse generator to deliver pulse bursts to said first chamber of said heart and by employing a defibrillation pulse generator means to deliver high energy pulses to said first chamber of said heart means in conjunction with delivery of said pulse bursts to said first chamber of said heart.

34. A method according to any of claims 30, 31, 32 or 33, further comprising:

sensing depolarizations of a second chamber of said heart; and

wherein said high energy pulse delivery step comprises delivering said high energy pulse in response to a sensed depolarization of said second chamber of said heart, after said high voltage capacitor is charged.

31. A method of providing a combined defibrillation therapy, comprising:

detecting fibrillation in a first chamber of said heart;

delivering a combined defibrillation therapy in response to detection of fibrillation in said first chamber of said heart by initiating charging of a high voltage output capacitor and defining a first time interval which will expire after charging of said high voltage capacitor, and delivering a low energy pulse burst to said first chamber of said heart commencing on the beginning of said first time interval and continuing until said high voltage capacitor is charged and discharging said high voltage capacitor to deliver a high energy pulse to said first chamber of said heart means in response to said high voltage capacitor being charged.

32. A method according to claim 31 wherein said pulse burst delivery step comprises terminating delivery of said pulse burst on expiration of said first time interval.

33. A method according to claim 32 wherein said pulse burst delivery step comprises terminating delivery of said pulse burst prior to delivery of said high energy pulse.