Dual chamber pacing system and method with control of AV interval

• US 5,713,930 A
• Filed: 11/06/1996
• Issued: 02/03/1998
• Est. Priority Date: 11/06/1996
• Status: Expired due to Term

• Current Assignee: Vitatron Medical BV
• Original Assignee: Vitatron Medical BV
• Inventors: van der Veen, Johannes S., van Oort, Geeske
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/744,576
• Time in Patent Office: 454 Days
• Field of Search: 607/9, 607/25, 607/28
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A dual chamber pacemaker system and method is provided for adjusting AV delay to provide for an optimal AV setting for a selected pacing application. In the inventive system and method, the basis for determining the AV delay setting is to perform a ventricular fusion test, wherein variations in QT interval are monitored corresponding to variations in AV interval. Based upon the AV-QT data, the pacemaker can determine the ventricular fusion zone where the pacemaker AV interval is substantially the same as the intrinsic conduction interval, as well as the knee where AV intervals just shorter than the ventricular fusion zone result in full capture. The pacemaker selects a routine for adjusting AV interval depending upon a desired application, including the applications of adjusting AV interval for full capture and for treatment of a HOCM patient. There is also provided a routine for determining an appropriate AV hysteresis value for inhibiting ventricular pacing and allowing ventricular sensing as much as possible, for patients with intermittent AV block.

Claims

1. A dual chamber pacemaker system, said pacemaker having ventricular pacing means for generating ventricular pace pulses for delivery to a patient'"'"'s ventricle, atrial pacing means for generating atrial pace pulses for delivery to the patient'"'"'s atrium, atrial sense means for sensing patient atrial contractions, AV means for timing out an AV interval for timing delivery of a ventricular pace pulse following an atrial sense or pace, and test means for determining the relationship between AV intervals and QT intervals, said test means comprising:

varying means for varying said AV interval to predetermined respective values,

measuring means for measuring T-waves and obtaining a measure of QT interval corresponding to each respective AV value;

means for determining from said corresponding QT and AV intervals when said AV intervals correspond to capture and when said AV intervals correspond to fusion; and

said AV means having AV control means for setting said AV interval as a function of said determining.

2. The pacemaker system as described in claim 1, further comprising selection means for selecting one of a plurality of applications, and wherein said AV control means controls said AV interval as a function of said selected application.

3. The pacemaker system as described in claim 2, wherein said selection means comprises means for selecting a hypertrophic obstructive cardiomyopathy (HOCM) application which controls said AV interval to be just less that corresponding to ventricular fusion.

4. The pacemaker system as described in claim 2, wherein said selection means comprises capture means for enabling selection of an application which controls said AV interval to be of a value which insures full capture upon delivering of a ventricular pace pulse.

5. The pacemaker system as described in claim 1, wherein said varying means comprises means for varying AV interval to each of n predetermined values and maintaining each respective AV interval value for a predetermined number of cycles.

6. The pacemaker system as described in claim 1, further comprising T-wave means for determining when T-waves are not sensed following a delivered ventricular pace pulse.

7. A method in a dual chamber pacemaker system for setting an AV interval value for achieving a selected application, comprising:

varying AV interval over a predetermined range of values;

determining QT intervals that correspond to respective AV intervals in said range;

analyzing said QT and AV intervals and determining therefrom whether said AV intervals correspond to capture or ventricular fusion; and

setting said AV interval value as a function of said determining.

8. The method as described in claim 7, comprising determining from said QT and AV intervals a measure of the patient'"'"'s ventricular fusion zone, and setting said AV interval value as a function of said ventricular fusion zone measure.

9. A dual chamber pacemaker system, having atrial sense means for sensing atrial signals from a patient, ventricular sense means for sensing ventricular signals from a patient, ventricular pace means for generating and delivering ventricular pace pulses to said patient'"'"'s right ventricle, and sync control means for controlling said pace means to generate and deliver a ventricular pace pulse at a controlled AV escape interval following a sensed atrial signal, said sync control means having AV_esc means for setting said AV escape interval, said AV_esc means comprising:

QT means for determining data representative of the variation of QT as a function of varying AV escape interval,

determining means for determining from said QT data a measure of the ventricular fusion zone, and

adjusting means for adjusting said AV escape interval as a function of said ventricular fusion zone measure.

10. The pacemaker system as described in claim 9, comprising application means for storing data representative of a desired pacing application and wherein adjusting means has enabling means for adjusting said AV escape interval in accordance with said application data following a ventricular fusion zone determination.

11. The pacemaker system as described in claim 10, wherein said adjusting means comprises means for determining the QT knee and for setting said AV delay to correspond to a QT value just less than said QT knee.

12. The pacemaker as described in claim 9, comprising means for determining the higher limit of the ventricular fusion zone, so as to maximize the occurrence of natural ventricular heartbeats.

13. The pacemaker as described in claim 9, further comprising hysteresis means for setting a hysteresis value of said AV escape interval as a function of said venticular fusion zone measure.