Method and apparatus for determining atrial lead disclocation and confirming diagnosis of atrial tachyarrhythimias

• US 5,713,932 A
• Filed: 10/28/1996
• Issued: 02/03/1998
• Est. Priority Date: 10/28/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gillberg, Jeffrey M., Brown, Mark L.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/738,769
• Time in Patent Office: 463 Days
• Field of Search: 607/4, 607/5, 607/9, 607/25, 607/27, 607/28, 607/63
• US Class Current: 607/27
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/3931 Protecting, e.g. back-up systems

Abstract

In a dual chamber cardiac stimulators, e.g. cardiac pacemaker or pacemaker/cardioverter/defibrillator (PCD) system, which relies upon the detection of atrial depolarizations or the stimulation of the atria in the performance of a defined function, a method and apparatus for determining the existence of an atrial pace/sense electrode(s) dislocation from an atrial site to a position inferior to the AV node of the heart thereby affecting a function, e.g. providing a false indication of atrial tachyarrhythmia. The determination of the occurrence of a dislocation of the atrial pace/sense electrode is effected by applying a test pace pulse to the atrial pace/sense electrode; detecting the immediately following ventricular depolarization from a ventricular sense electrode; measuring the interval between the delivered atrial pace pulse and the detected ventricular depolarization; comparing the measured interval to a threshold AV interval; and determining that the atrial pace/sense electrode is in contact with the right atrium if the measured interval is longer than the threshold AV interval. Preferably, the determination is effected by: providing a first signal when the measured AV interval exceeds the threshold AV interval and a second signal when the measured AV interval is less than the threshold AV interval; applying a series of M atrial pace pulses to the atrial pace/sense electrode; counting the number of first and second signals provided in response to the series of atrial pace pulses; and determining that the atrial pace/sense electrode is located in the right atrium when a number of first signals are provided in a series of delivered atrial pace pulses. Confirmation of a provisional tachyarrhythmia is also made from the number of first and second signals.

Claims

1. A method of determining the location of the atrial pace/sense electrode(s) of an atrial pace lead in a cardiac stimulation system of the type comprising a timing and control sub-system, an atrial pulse generator coupled with the atrial pace lead for providing atrial pace pulses to the atrial pace lead, a ventricular sense amplifier coupled with a ventricular sense lead having ventricular sense electrode(s) positioned in contact with the ventricle for providing a ventricular sense signal to the timing and control sub-system, the method comprising the steps of operating the timing and control sub-system in:

(a) providing a threshold AV delay interval correlated with the AV conduction time of an atrial depolarization wave originating in the atrium and eliciting a responsive ventricular depolarization wave conducted in the ventricular septum;

(b) operating the atrial pulse generator to generate and apply an atrial pace pulse to the atrial pace electrode(s);

(c) sensing, through operation of the ventricular sense amplifier, the following ventricular depolarization at the ventricular sense electrode(s) as a ventricular sense event;

(d) measuring the time interval between the applied atrial pace pulse and the ventricular sense event as a measured AV delay interval;

(e) comparing the measured AV delay interval to the threshold AV delay interval; and

(f) determining that the atrial pace electrode(s) is in contact with the right atrium if the measured AV delay interval is longer than the threshold AV delay interval.

2. The method of claim 1 wherein the determining step (f) comprises the steps of:

repeating steps (b)-(e) to derive M measured AV delay intervals and comparisons with the threshold AV delay interval; and

determining that the atrial pace electrode(s) of the atrial lead are located in the right atrium when at least a number N2 of the M measured AV delay intervals are longer than the threshold AV delay interval.

3. The method of claim 2 wherein the determining step (f) further comprises the steps of:

determining that the atrial sense electrode(s) of the atrial lead are dislocated from the right atrium when a number N1 of the M measured AV delay intervals are shorter than the threshold AV delay interval.

4. The method of claim 1 further comprising the steps of:

repeating steps (b)-(e) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval; and

counting the number of first and second signals provided in response to the series of M atrial pace pulses; and

the determining step (f) comprises;

determining that the atrial pace electrode(s) of the atrial lead are located in the right atrium at a certain count of first signals.

5. The method of claim 4 wherein the determining step (f) further comprises the steps of:

determining that the atrial sense electrode(s) of the atrial lead are dislocated from the right atrium at a certain count of second signals.

6. The method of claim 1 wherein step (a) comprises the steps of:

measuring at least one V-V interval between successive ventricular sense events; and

selecting the threshold AV delay interval as a fraction of a normal AV conduction time for the prevailing measured V-V interval(s).

7. The method of claim 1 wherein step (b) comprises the steps of:

measuring at least one V-V interval between successive ventricular sense events;

calculating a V-A escape interval as a fraction of the measured V-V interval(s);

timing the calculated V-A escape interval from a ventricular sense event; and

triggering the generation of the atrial pace pulse at the time-out of the calculated V-A escape interval.

8. Apparatus for determining the location of the atrial pace electrode(s) of an atrial pacing lead in a cardiac stimulation system of the type comprising a timing and control sub-system, an atrial pulse generator coupled with the atrial pace lead for providing atrial pace pulses to the atrial pace lead, and a ventricular sense amplifier coupled with a ventricular sense lead having ventricular sense electrode(s) positioned in contact with the ventricle for providing a ventricular sense signal to the timing and control sub-system, the apparatus further comprising:

(a) means for providing a threshold AV delay interval correlated with the AV conduction time of an atrial depolarization wave originating in the atrium and eliciting a responsive ventricular depolarization wave conducted in the ventricular septum;

(b) means for operating the atrial pulse generator to generate and apply an atrial pace pulse to the atrial pace electrode(s);

(c) means for sensing, through operation of the ventricular sense amplifier, the following ventricular depolarization at the ventricular sense electrode(s) as a ventricular sense event;

(d) means for measuring the time interval between the applied atrial pace pulse and the ventricular sense event as a measured AV delay interval;

(e) means for comparing the measured AV delay interval to the threshold AV delay interval; and

(f) means for determining that the atrial pace electrode(s) is in contact with the right atrium if the measured AV delay interval is longer than the threshold AV delay interval.

9. The apparatus of claim 8 wherein the determining means further comprises:

means for operating means (b)-(e) to derive M measured AV delay intervals and comparisons with the threshold AV delay interval; and

means for determining that the atrial pace electrode(s) of the atrial lead are located in the right atrium when a certain count N2 of the M measured AV delay intervals are consistently longer than the threshold AV delay interval.

10. The apparatus of claim 9 wherein the determining means (f) comprises:

means for determining that the atrial sense electrode(s) of the atrial lead are dislocated from the right atrium when a certain count N1 of the M measured AV delay intervals are shorter than the threshold AV delay interval.

11. The apparatus of claim 9 wherein the determining means (f) comprises:

means for operating means (b)-(e) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

means for providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

means for providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval;

means for counting the number of first and second signals provided in response to the series of M atrial pace pulses; and

means for determining that the atrial pace electrode(s) of the atrial lead are located in the right atrium at a certain count of first signals.

12. The apparatus of claim 11 wherein the determining means (f) further comprises:

means for determining that the atrial sense electrode(s) of the atrial lead are dislocated from the right atrium at a certain count of second.

13. The apparatus of claim 8 further wherein the threshold AV delay interval providing means (a) further comprises:

means for measuring the V-V interval between successive ventricular sense events; and

means for selecting the threshold AV delay interval as a fraction of a normal AV conduction time for the prevailing sensed V-V interval.

14. The apparatus of claim 8 wherein:

the means (b) for operating the atrial pulse generator further comprises;

means for measuring at least one V-V interval between successive ventricular sense events; and

means for calculating a V-A escape interval as a fraction of the measured V-V interval(s); and

the means for operating the atrial pulse generator further comprises;

means for timing the calculated V-A escape interval from a ventricular sense event; and

means for triggering the generation of the atrial pace pulse at the time-out of the calculated V-A escape interval.

15. A method of confirming a provisional diagnosis of an atrial tachyarrhythmia in a dual chamber, anti-tachyarrhythmia cardiac stimulation system of the type comprising a timing and control sub-system, an atrial sense amplifier and atrial pulse generator coupled with an atrial pace/sense lead, the atrial sense amplifier providing atrial sense signals to the timing and control sub-system and the atrial pulse generator providing atrial pace pulses to the atrial pace/sense lead, a ventricular sense amplifier coupled with a ventricular sense lead having ventricular sense electrode(s) positioned in contact with the ventricle for providing a ventricular sense signal to the timing and control sub-system, the method comprising the steps of operating the timing and control sub-system in:

(a) provisionally diagnosing the existence of an atrial tachyarrhythmia from the atrial sense signals;

(b) providing a threshold AV delay interval correlated with the AV conduction time of an atrial depolarization wave originating in the atrium and eliciting a responsive ventricular depolarization wave conducted in the ventricular septum;

(c) operating the atrial pulse generator to generate and apply an atrial pace pulse to the atrial pace/sense electrode(s);

(d) sensing, through operation of the ventricular sense amplifier, the following ventricular depolarization at the ventricular sense electrode(s) as a ventricular sense event;

(e) measuring the time interval between the applied atrial pace pulse and the ventricular sense event as a measured AV delay interval;

(f) comparing the measured AV delay interval to the threshold AV delay interval;

(g) confirming the provisional diagnosis when the measured AV delay interval is longer than the threshold AV delay interval signifying that the atrial pace/sense electrode(s) are located within the right atrium.

16. The method of claim 15 further comprising the steps of:

repeating steps (c)-(f) to derive M measured AV delay intervals and comparisons with the threshold AV delay interval; and

wherein the confirming step (g) further comprises;

confirming the provisional diagnosis of atrial tachyarrhythmias when a certain count N1 of the M measured AV delay intervals are consistently longer than the threshold AV delay interval indicating that the atrial pace/sense electrode(s) of the atrial lead are located in the right atrium.

17. The method of claim 16 further comprising the step of:

(h) canceling the provisional diagnosis of an atrial tachyarrhythmia when a certain count N2 of the M measured AV delay intervals are consistently shorter than the threshold AV delay interval indicating that the atrial pace/sense electrode(s) of the atrial lead are dislocated from the right atrium.

18. The method of claim 15 further comprising the steps of:

repeating steps (c)-(f) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval; and

counting the number of first and second signals provided in response to the series of M atrial pace pulses; and

wherein the confirming step (g) comprises;

confirming the provisional diagnosis of an atrial tachyarrhythmia at a certain count of first signals.

19. The method of claim 18 wherein the confirming step (g) further comprises the steps of:

denying the confirmation of the atrial tachyarrhythmia at a certain count of second signals.

20. The method of claim 15 further comprising the steps of:

repeating steps (c)-(f) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval; and

counting the number of first and second signals provided in response to the series of M atrial pace pulses; and

the confirming step (g) further comprises;

confirming a provisional diagnosis of atrial tachyarrhythmia when the numbers of first and second signals are both greater than zero.

21. The method of claim 15 wherein step (b) comprises the steps of:

measuring at least one V-V interval between successive ventricular sense events; and

selecting the threshold AV delay interval as a fraction of a normal AV conduction time for the prevailing measured V-V interval(s).

22. The method of claim 15 further wherein step (c) comprises the steps of:

measuring at least one V-V interval between successive ventricular sense events;

calculating a V-A escape interval as a fraction of the measured V-V interval(s);

timing the calculated V-A escape interval from a ventricular sense event; and

triggering the generation of the atrial pace pulse at the time-out of the calculated V-A escape interval.

23. Apparatus for confirming a provisional diagnosis of an atrial tachyarrhythmia in a dual chamber, anti-tachyarrhythmia cardiac stimulation system of the type comprising a timing and control sub-system, an atrial sense amplifier and atrial pulse generator coupled with an atrial pace/sense lead, the atrial sense amplifier providing atrial sense signals to the timing and control sub-system and the atrial pulse generator providing atrial pace pulses to the atrial pace/sense lead, a ventricular sense amplifier coupled with a ventricular sense lead having ventricular sense electrode(s) positioned in contact with the ventricle for providing a ventricular sense signal to the timing and control sub-system, the apparatus further comprising:

(a) means for provisionally diagnosing the existence of an atrial tachyarrhythmia from the atrial sense signals;

(b) means for providing a threshold AV delay interval correlated with the AV conduction time of an atrial depolarization wave originating in the atrium and eliciting a responsive ventricular depolarization wave conducted in the ventricular septum;

(c) means for operating the atrial pulse generator to generate and apply an atrial pace pulse to the atrial pace/sense electrode(s);

(d) means for sensing, through operation of the ventricular sense amplifier, the following ventricular depolarization at the ventricular sense electrode(s) as a ventricular sense event;

(e) means for measuring the time interval between the applied atrial pace pulse and the ventricular sense event as a measured AV delay interval;

(f) means for comparing the measured AV delay interval to the threshold AV delay interval;

(g) means for confirming the provisional diagnosis of atrial tachyarrhythmia if the measured AV delay interval is longer than the threshold AV delay interval.

24. The apparatus of claim 23 further comprising:

means for employing means (c)-(f) to derive M measured AV delay intervals and comparisons with the threshold AV delay interval; and

wherein the confirming means (g) comprises;

means for confirming the provisional diagnosis of atrial tachyarrhythmias when at least N1 of the M measured AV delay intervals are longer than the threshold AV delay interval.

25. The apparatus of claim 24 wherein said confirming means (g) further comprises:

means for canceling the provisional diagnosis of atrial tachyarrhythmia when at least N2 of the M measured AV delay intervals are shorter than the threshold AV delay interval.

26. The apparatus of claim 23 further comprising:

means for operating means (c)-(f) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

means for providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

means for providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval; and

means for counting the number of first and second signals provided in response to the series of N atrial pace pulses; and

wherein the confirming means (g) comprises;

means for confirming the provisional diagnosis of an atrial tachyarrhythmia at a certain count of first signals.

27. The apparatus of claim 26 wherein the confirming means (g) further comprises:

means for denying the confirmation of the atrial tachyarrhythmia at a certain count of second signals.

28. The apparatus of claim 23 further comprising:

means for operating means (c)-(f) to derive M measured AV intervals and comparisons with the threshold AV delay interval;

means for providing a first signal each time that the measured AV delay interval exceeds the threshold AV delay interval;

means for providing a second signal each time that the measured AV delay interval is less than the threshold AV delay interval; and

means for counting the number of first and second signals provided in response to the series of atrial pace pulses; and

the confirming means (g) further comprises;

means for confirming a provisional diagnosis of atrial fibrillation when the numbers of first and second signals are both greater than zero.

29. The apparatus of claim 23 wherein the means (b) for providing a threshold AV delay interval further comprises:

means for measuring at least one V-V interval between successive ventricular sense events; and

means for selecting the threshold AV delay interval as a fraction of a normal AV conduction time for the prevailing measured V-V interval(s).

30. The apparatus of claim 23 further wherein the means (c) for operating the atrial pulse generator comprises:

means for measuring at least one V-V interval between successive ventricular sense events;

means for calculating a V-A escape interval as a fraction of the measured V-V interval(s);

means for timing the calculated V-A escape interval from a ventricular sense event; and

means for triggering the generation of the atrial pace pulse at the time-out of the calculated V-A escape interval.