Emulsion for robust sensing
First Claim
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1. A gas sensing composition, comprising:
- a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains at least one substantially water soluble emulsification enhancement agent;
at least one water soluble indicator component effective to provide a signal in response to the concentration of a gas in a medium to which the sensing composition is exposed, and a humectant; and
a hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the second phase contains at least one substantially water insoluble emulsification enhancement agent.
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Abstract
The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO2 or ammonia) in a medium such as blood which has superior dry web sensor performance, enhanced sensor consistency for transparent sensor calibration, improved autoclave stability and rapid rehydration of the sensor. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive indicator component and a nonionic amphipathic surfactant within a hydrophobic barrier phase comprising a plurality of dispersed hydrophobic particles.
63 Citations
47 Claims
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1. A gas sensing composition, comprising:
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a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains at least one substantially water soluble emulsification enhancement agent;
at least one water soluble indicator component effective to provide a signal in response to the concentration of a gas in a medium to which the sensing composition is exposed, and a humectant; anda hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the second phase contains at least one substantially water insoluble emulsification enhancement agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A dry gas sensing composition, comprising:
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a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains a humectant and at least one soluble indicator component effective to provide a signal in response to the concentration of an analyte in a medium to which the sensing composition is exposed; and a hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the sensing composition provides an effective signal in response to the gas when the medium is dry. - View Dependent Claims (39, 40, 41, 42)
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43. A dry gas sensing composition, comprising:
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a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains glycerol and at least one soluble indicator component effective to provide a signal in response to the concentration of an analyte in a medium to which the sensing composition is exposed; and a hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the sensing composition provides an effective signal in response to the gas when the medium is dry. - View Dependent Claims (44, 45, 46, 47)
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Specification