Delivery system comprising means for governing fluid ingress into the system

• US 5,714,160 A
• Filed: 04/03/1996
• Issued: 02/03/1998
• Est. Priority Date: 12/13/1988
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Peery, John R., Cortese, Richard
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US08/627,169
• Time in Patent Office: 671 Days
• Field of Search: 424/422, 424/423, 424/438, 424/473, 424/486, 424/484, 424/426
• US Class Current: 424/438
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

Claims

1. A delivery system for delivering a beneficial agent to a fluid biological environment of use, wherein the delivery system comprises:

(1) a housing member comprising;

(2) a lead end and a rear end;

(3) an exit in the lead end;

(4) a wall closed and continuous the length of the housing member;

the wall comprising;

(5) a first section impermeable to the passage for fluid and joined in a fluid tight arrangement with;

(6) a second section permeable to the passage for fluid;

(7) in the first section;

(a) a beneficial agent that is sensitive to fluid; and

(b) a carrier for the beneficial agent, wherein said first section protects the beneficial agent from fluid in the environment of use;

(8) an osmopolymer as push means in the second section for delivering the beneficial agent through the exit from the delivery system; and

(9) a layer interposed between the first and second sections, said layer being sufficiently impermeable to restrict passage for fluid from the second section into the first, beneficial agent, section, said layer acting to slide into the first section, aiding in the delivery of beneficial agent, when the push means expands.

2. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a somatotropin.

3. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is porcine somatotropin.

4. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a hormone.

5. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a somatotropin analogue.

6. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a bovine somatotropin.

7. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises glycerol.

8. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises a surfactant.

9. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the carrier comprises a buffer.

10. A method for delivering a somatotropin to an animal wherein the method comprises admitting into the animal a delivery system according to claim 2.

11. The delivery system according to claim 1, wherein said first section is manufactured from a composition comprising a different polymer than the polymer from which said second section is manufactured, and wherein said first and second sections are joined to define a closed continuous wall.