Platinum-containing compounds, methods for their preparation and applications thereof
First Claim
1. A detectable probe compound, having the structure:
- ##STR35## wherein;
Pt is a platinum atom;
PROBE is a probe biomolecule;
M is a detectable marker moiety; and
X and Y are stabilizing substituents.
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Abstract
The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other PtII and PtIV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.
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Citations
21 Claims
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1. A detectable probe compound, having the structure:
- ##STR35## wherein;
Pt is a platinum atom;PROBE is a probe biomolecule; M is a detectable marker moiety; and X and Y are stabilizing substituents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- ##STR35## wherein;
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11. A method for detecting a biological target molecule, comprising:
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(a) providing to a testable system a platinum-based detectably labeled probe having the structure;
##STR36## wherein;
Pt is a platinum atom,PROBE is a probe biomolecule for associating to a biological target molecule, M is a detectable marker moiety, and X and Y are stabilizing substituents; and (b) measuring an amount of association between said detectably labeled probe and said target biomolecule. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of detectably labeling a biomolecule, comprising:
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reacting a detectable label compound having the structure;
##STR37## wherein;
Pt is a platinum atom;M is a detectable marker moiety; A is a displaceable leaving group; and X and Y are stabilizing substituents, with a biomolecule which is to be detectably labeled.
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Specification