Method of treating movement disorders by brain stimulation

• US 5,716,377 A
• Filed: 04/25/1996
• Issued: 02/10/1998
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T., King, Gary W.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/637,366
• Time in Patent Office: 656 Days
• Field of Search: 607/1, 607/2, 607/3, 607/43, 607/45, 607/46, 607/6, 607/72
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003

Abstract

Techniques for stimulating the brain to treat movement disorders resulting in abnormal motor behavior by means of an implantable signal generator and electrode. A sensor is used to detect the symptoms resulting from the motion disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation delivered to the brain.

Claims

1. A method of therapeutically treating a movement disorder resulting in abnormal motor behavior by means of a signal generator and an implantable electrode having a proximal end and a stimulation portion comprising the steps of:

surgically implanting said electrode in a brain of a patient so that the stimulation portion lies in communication with a predetermined treatment site in the brain, said predetermined treatment site being selected from the group consisting of the pallido-thalamic axons (AL), the lenticulo-thalamic fiber pathway (LT), substantia nigra pars reticulata (SNr), external segment of globus pallidus (GPe), subthalamic to pallidal fiber tracts, putamen, and putamen to GPe fibers;

coupling said proximal end of said electrode to said signal generator; and

operating said signal generator to stimulate said predetermined treatment site in the brain,

whereby the symptoms of said movement disorder are reduced.

2. A method, as claimed in claim 1, wherein said movement disorder is a hyperkinetic disorder and wherein said stimulation is selected to reduce thalamic output.

3. A method, as claimed in claim 2, wherein said hyperkinetic disorder comprises dystonia, ballism, hemiballism, chorea, athetosis, torticollis, or spasticity.

4. A method, as claimed in claim 2, wherein said stimulation is selected to decrease excitement of the thalamus or increase inhibition of the thalamus.

5. A method, as claimed in claim 4, wherein said stimulation is selected to decrease inhibition or increase excitation of said internal segment of globus pallidus (GPi), substantia nigra pars reticulata (SNr) or subthalamic nucleus (STN) that inhibit thalamic output.

6. A method, as claimed in claim 4, wherein said stimulation is selected to decrease excitation or increase inhibition of said external segment of globus pallidus (GPe).

7. A method, as claimed in claim 6, wherein said stimulation comprises pulses having a repetition rate of 2 to 2500 Hz.

8. A method, as claimed in claim 1, wherein said movement disorder is a hypokinetic disorder and wherein said stimulation is selected to increase thalamic output.

9. A method, as claimed in claim 8, wherein said hypokinetic disorder comprises akinesia, rigidity, or bradykinesia.

10. A method, as claimed in claim 8, wherein said stimulation is selected to increase excitement of the thalamus or decrease inhibition of the thalamus.

11. A method, as claimed in claim 10, wherein said stimulation is selected to increase inhibition or decrease excitation of said internal segment of globus pallidus (GPi), substantia nigra pars reticulata (SNr) or subthalamic nucleus (STN) that inhibit thalamic output.

12. A method, as claimed in claim 10, wherein said stimulation is selected to increase excitation or decrease inhibition of said external segment of globus pallidus (GPe).

13. A method of treating a movement disorder resulting in abnormal motor behavior comprising in combination:

implanting a signal generator in a body;

implanting at least one electrode in at least one predetermined site in a brain of said body;

coupling said at least one electrode to said signal generator;

generating a signal related to the extent of said abnormal motor behavior;

generating stimulation pulses with said signal generator; and

regulating said stimulation pulses in response to said signal, whereby the stimulation is increased in response to an increase in said abnormal motor behavior and is decreased in response to a decrease in said abnormal motor behavior.

14. A method, as claimed in claim 13, wherein said step of generating a signal comprises the step of generating a signal corresponding to the extent of abnormal motion resulting from said abnormal motor behavior.

15. A method, as claimed in claim 13, the step of generating a signal comprises the step of detecting changes in electromagnetic waves generated by muscle.

16. A method, as claimed in claim 13, wherein said step of regulating comprises the step of executing a control algorithm.

17. A method, as claimed in claim 16, wherein said step of generating said signal comprises the steps of detecting said abnormal motor behavior and communicating with said algorithm by telemetry.

18. A method, as claimed in claim 13, wherein said movement disorder is a hyperkinetic disorder or a hypokinetic disorder.