Crural diaphragm pacemaker and method for treating esophageal reflux disease

• US 5,716,385 A
• Filed: 11/12/1996
• Issued: 02/10/1998
• Est. Priority Date: 11/12/1996
• Status: Expired due to Fees

• Current Assignee: University of Virginia
• Original Assignee: University of Virginia
• Inventors: Ross, Robert, Liu, Jiamnim, Mittal, Ravinder K., Schirmer, Bruce
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/747,513
• Time in Patent Office: 455 Days
• Field of Search: 607/2, 607/40, 607/41, 128/898
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

An electronic pacemaker is used to counter-act crural diaphragm relaxation thereby preventing and/or treating gastroesophageal reflux. The pacemaker can be implantable, or be connected to the skeletal muscles of the crural diaphragm through the skin. A sensor is used to identify spontaneous intermittent relaxations of the diaphragm. During these spontaneous intermittent relaxations, one or more electrodes are used to stimulate the skeletal muscles of the crural diaphragm to cause contraction of the lower esophageal sphincter.

Claims

1. A crural diaphragm pacemaker, comprising:

means for sensing crural diaphragm inhibition; and

means for providing electrical stimulation to a patient'"'"'s crural diaphragm.

2. The crural diaphragm pacemaker of claim 1 further comprising means for determining a time period when a patient is experiencing transient lower esophageal sphincter relaxation, said means for providing electrical stimulation being selectively activated during said time period.

3. The crural diaphragm pacemaker of claim 2 further comprising means for monitoring a patient'"'"'s costal diaphragm.

4. The crural diaphragm pacemaker of claim 3 wherein said means for providing electrical stimulation includes a means for providing electrical stimuli to said patient'"'"'s crural diaphragm at the same frequency as contractions of said patient'"'"'s costal diaphragm sensed by said means for monitoring.

5. The crural diaphragm pacemaker of claim 1 wherein said means for providing electrical stimulation includes a means for providing electrical stimulus to said patient'"'"'s crural diaphragm only when crural diaphragm inhibition is sensed.

6. The crural diaphragm pacemaker of claim 1 wherein said means for providing electrical stimulation includes a means for providing electrical stimulus to said patient'"'"'s crural diaphragm on an intermittent basis.

7. A crural diaphragm pacemaker, comprising:

a crural diaphragm electrode connectable to a patient'"'"'s crural diaphragm; and

a controller connected to said crural diaphragm electrode, said controller selectively directing said crural diaphragm electrode to provide electrical stimulation to a patient'"'"'s crural diaphragm.

8. The crural diaphragm pacemaker of claim 7 further comprising costal diaphragm electrode connectable to a patient'"'"'s costal diaphragm, said costal diaphragm electrode being connected to said controller and providing signals representative of a patient'"'"'s costal diaphragm contractions.

9. The crural diaphragm pacemaker of claim 8 wherein said controller directs said crural diaphragm electrode to provide electrical stimulation to a patient'"'"'s crural diaphragm at substantially the same frequency as a patient'"'"'s costal diaphragm contractions sensed with said costal diaphragm electrode.

10. The crural diaphragm pacemaker of claim 7 wherein said crural diaphragm electrode functions to both sense inhibition of a patient'"'"'s crural diaphragm and provide electrical stimulation to a patient'"'"'s crural diaphragm.

11. The crural diaphragm pacemaker of claim 7 further comprises a means for programming said controller to adjust any one of the parameters selected from the group consisting of stimulation level, stimulation frequency, enablement of stimulation, and duty cycle.

12. The crural diaphragm pacemaker of claim 7 further comprising a communications interface module which communicates with said controller.

13. A method for treating gastroesophageal reflux, comprising the steps of:

sensing spontaneous intermittent relaxations of a patient'"'"'s crural diaphragm; and

providing sufficient electrical stimulation to said patient'"'"'s crural diaphragm to cause contraction of said patient'"'"'s lower esophageal sphincter.

14. The method of claim 13 wherein said step of providing electrical stimulation is performed intermittently.

15. A method of electrically pacing a patient'"'"'s crural diaphragm, comprising the steps of:

detecting crural diaphragm inhibition for said patient; and

electrically stimulating said patient'"'"'s crural diaphragm when crural diaphragm inhibition is detected during said detecting step.

16. The method of claim 15 further comprising the step of detecting said patient'"'"'s costal diaphragm contractions, said step of electrically stimulating being performed when said patient'"'"'s crural diaphragm is inhibited and said patient'"'"'s costal diaphragm is functioning normally.

17. The method of claim 16 wherein said step of electrically stimulating is performed at the same frequency as said patient'"'"'s crural diaphragm contractions.