Method for treating cardiac malfunction
First Claim
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1. A method for producing a positive inotropic effect in a mammalian host by administering to the host a positive inotropic effect-producing amount of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity.
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Abstract
A method of treating cardiac malfunction by administering a positive inotropic effect-producing amount of Hypothalamic Inhibitory factor (HIF).
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Citations
8 Claims
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1. A method for producing a positive inotropic effect in a mammalian host by administering to the host a positive inotropic effect-producing amount of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity.
- 2. A method for treating cardiac malfunction in a mammal suffering therefrom by administering a positive inotropic effect-producing amount of a glycosidic Hypothalamic Inhibitory Factor to said mammal, said Hypothalamic Inhibitory Factor specifically binding sodium, potassium-AtPase reversibly and with high affinity wherein said Factor has been purified to homogeneity.
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4. A method of treating a mammal with cardiac glycoside intoxication comprising administering to the mammal a therapeutically effective amount of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity, to treat said cardiac glycoside intoxication and a therapeutically acceptable carrier.
- 5. A method for treating a mammal with an edematous disorder comprising administering a therapeutically effective amount of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity, to the mammal.
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7. A method of treating a mammal with hypertension comprising administering to the mammal an analogue of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity, to prevent or modulate the binding of native Hypothalamic Inhibitory Factor.
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8. A method of treating a mammal with hypotension comprising administering to the mammal a therapeutically effective amount of a glycosidic Hypothalamic Inhibitory Factor, wherein said Factor has been purified to homogeneity.
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