Anti-angiogenic compositions and methods of use

• US 5,716,981 A
• Filed: 06/07/1995
• Issued: 02/10/1998
• Est. Priority Date: 07/19/1993
• Status: Expired due to Term

• Current Assignee: Angiotech Pharmaceuticals Incorporated
• Original Assignee: Angiogenesis Technologies Incorporated
• Inventors: Hunter, William L., Machan, Lindsay S., Arsenault, A. Larry
• Primary Examiner(s): Kumar, Shailendra
• Application Number:
  US08/478,203
• Time in Patent Office: 979 Days
• Field of Search: 604/53, 604/20, 604/21, 604/96, 604/269, 128/898, 514/449, 606/198, 623/12, 528/421, 526/304
• US Class Current: 514/449
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/136 having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/335 having oxygen as the only ring hetero atom, e.g. fungichromin
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 38/57 from animals; from humans A61K38/553, A61K38/556 take precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/50 the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• CPC Class Codes: A61K 47/6927 the form being a solid microparticle having no hollow or gas-filled cores
• CPC Class Codes: A61K 47/6957 the form being a device or a kit, e.g. stents or microdevices
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61K 9/167 with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface with further drug-free outer coating A61K9/5073
• CPC Class Codes: A61K 9/5153 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5161 : Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
• CPC Class Codes: A61K 9/5169 : Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61K 9/7007 : Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61L 2300/416 : Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/606 : Coatings
• CPC Class Codes: A61L 2300/622 : Microcapsules
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: A61L 31/145 : Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C07K 14/811 : Serine protease (E.C. 3.4.21) inhibitors
• CPC Class Codes: C08L 2203/02 : for biomedical use
• CPC Class Codes: C08L 23/08 : Copolymers of ethene C08L23/16 takes precedence
• CPC Class Codes: C08L 23/0853 : Vinylacetate
• CPC Class Codes: C08L 2312/00 : Crosslinking
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Claims

1. a stent for expanding the lumen of a body passageway, comprising a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier.

2. a stent according to claim 1 wherein said polymeric carrier comprises poly (caprolactone).

3. a stent according to claim 1 wherein said polymeric carrier comprises poly (lactic acid).

4. a stent according to claim 1 wherein said polymeric carrier comprises poly (ethylene-vinyl acetate).

5. a stent according to claim 1 wherein said polymeric carrier comprises a copolymer of poly caprolactone and poly lactic acid.

6. a stent according to claim 1 wherein said stent is a vascular stent.

7. a stent according to claim 1 wherein said stent is a biliary stent.

8. a stent according to claim 1 wherein said stent is a urethral stent.

9. a stent according to claim 1 wherein said stent is an esophageal stent.

10. a stent according to claim 1 wherein said stent is a tracheal/bronchial stent.

11. a method for expanding the lumen of a body passageway, comprising inserting a stent into the passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said passageway is expanded.

12. a method for eliminating vascular obstructions, comprising inserting a vascular stent into a vascular passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said vascular obstruction is eliminated.

13. a method for eliminating biliary obstructions, comprising inserting a biliary stent into a biliary passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said biliary obstruction is eliminated.

14. a method for eliminating urethral obstructions, comprising inserting a urethral stent into a urethra, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said urethral obstruction is eliminated.

15. a method for eliminating esophageal obstructions, comprising inserting an esophageal stent into an esophagus, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said esophageal obstruction is eliminated.

16. a method for eliminating tracheal/bronchial obstructions, comprising inserting a tracheal/bronchial stent into the trachea or bronchi, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said tracheal/bronchial obstruction is eliminated.

17. a method for treating or preventing narrowing of a blood vessel, comprising inserting a stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said narrowing is treated or prevented.

18. The method according to claim 17 wherein said narrowing of a blood vessel is due to recurrent stenosis.