Antimicrobial cleansing composition containing chlorhexidine, an amphoteric surfactant, and an alkyl polyglucoside

• US 5,719,113 A
• Filed: 08/28/1996
• Issued: 02/17/1998
• Est. Priority Date: 05/20/1994
• Status: Expired due to Term

• Current Assignee: GOJO Industries Incorporated
• Original Assignee: GOJO Industries Incorporated
• Inventors: Williams, Ronald A., Dolan, Michael J., Fendler, Eleanor J.
• Primary Examiner(s): Lieberman, Paul
• Assistant Examiner(s): Fries, Kery A.
• Application Number:
  US08/704,135
• Time in Patent Office: 538 Days
• Field of Search: 510/123, 510/124, 510/131, 510/132, 510/161, 510/382, 510/384, 510/470, 510/504, 510/499
• US Class Current: 510/382
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 8/604 Alkylpolyglycosides; Derivatives thereof, e.g. esters
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: C11D 1/662 Carbohydrates or derivatives
• CPC Class Codes: C11D 1/90 Betaines
• CPC Class Codes: C11D 1/94 Mixtures with anionic, cationic or non-ionic compounds
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

A cleansing composition includes a salt of chlorhexidine such as chlorhexidine digluconate and at least one nonionic surfactant which does not include any polyoxypropylene/polyoxyethylene block copolymers. Also included in the composition is at least one amphoteric surfactant. Other additives such as viscosifiers or thickeners, emollients, fragrances, perfumes, coloring agents, preservatives, foaming agents, fungicides and the like may also be added. Preferably, the composition does not include alcohol as a carrier. The cleansing composition has been found to exhibit improved antibacterial properties while remaining mild on the skin.

Claims

1. An antimicrobial cleansing composition comprising:

an effective amount of a salt of chlorhexidine for providing antimicrobial activity to the cleansing composition;

an amount of at least one alkyl polyglucoside effective for not substantially reducing the antimicrobial activity of said salt of chlorhexidine; and

an amphoteric surfactant selected from the group consisting of an alkyl phosphatidyl propylene glycol-dimonium chloride and an alkylammino carboxylate wherein in the alkyl group is 8 to 18 carbon atom in an amount effective for providing foaming properties;

said composition being devoid of any polyoxypropylene/polyoxyethylene block copolymers, any lower alkanols, and any alcohol diluents, and wherein said composition exhibits at least about a log 3 reduction against a bacteria selected from the group consisting of Staphylococcus aureus (ATCC #33591), Enterococcus faecium (ATCC #19434), Serratia marcescens (ATCC

     14756), Escherichia coli (ATCC

     8739), Pseudomonas aeruginosa (ATCC

     15442) in a 30 second exposure kill test.

2. An antimicrobial cleansing composition, as set forth in claim 1, wherein said salt of chlorhexidine is gluconate, acetate, formate, lactate, isethionate, succinamate, glutamate, mono-diglycollate, dimethanesulfonate, di-isobutyrate, or glucoheptonate.

3. An antimicrobial cleansing composition, as set forth in claim 2, wherein said salt is chlorhexidine digluconate.

4. An antimicrobial cleansing composition, as set forth in claim 1, wherein said alkyl polyglucoside has an alkyl chain length of from about C₈ to about C₁₆.

5. An antimicrobial cleansing composition, as set forth in claim 1, further comprising a non-aromatic alcohol ethoxylate selected from the group consisting of linear C_9-11 alcohol ethoxylate (EO=8), linear C_9-11 alcohol ethoxylate (EO=6), linear C₁₀ alcohol ethoxylate (EO=4), linear C₁₀ alcohol ethoxylate (EO=6), and linear C_8-10 alcohol ethoxylate (EO=2);

and said alkyl polyglucoside.

6. An antimicrobial cleansing composition, as set forth in claim 5, wherein said alcohol ethoxylate is a branched alcohol ethoxylate having less than 14 carbon atoms.

7. An antimicrobial cleansing composition, as set forth in claim 1, wherein said alkylammonio carboxylate having from 8 to 18 carbons atoms is cocobetaine.

8. An antimicrobial cleansing composition, as set forth in claim 1, further comprising a polymeric viscosifier.

9. An antimicrobial cleansing composition, as set forth in claim 8, wherein said polymeric viscosifier includes hydroxyethyl cellulose.

10. An antimicrobial cleansing composition, as set forth in claim 1, further comprising an acid to adjust the pH of the composition.

11. An antimicrobial cleansing composition, as set forth in claim 10, wherein said acid is selected from the group consisting of lactic acid, acetic acid, glycolic acid, citric acid, and gluconic acid.

12. An antimicrobial cleansing composition, as set forth in claim 1, having a pH between about 5.5 and 8.

13. An antimicrobial cleansing composition, as set forth in claim 1, further comprising a non-alcoholic carrier.

14. An antimicrobial cleansing composition, as set forth in claim 13, wherein said non-alcoholic carrier is water.

15. An antimicrobial cleansing composition, as set forth in claim 1, wherein said salt of chlorhexidine is present in an amount ranging between about 0.2 percent active by weight and about 5 percent active by weight of the total composition.

16. An antimicrobial cleansing composition, as set forth in claim 1, wherein said alkyl polyglucoside is present in an amount ranging from an effective amount for increasing the antimicrobial activity of said salt of chlorhexidine in water to about 10 percent active by weight of the total composition.

17. An antimicrobial cleansing composition, as set forth in claim 1, further comprising at least one additive selected from the group consisting of fragrances, perfumes, coloring agents, opacifying agents, pearlizing agents, vitamins, fungicides, antioxidants, emollients, skin care additives, and foaming agents.