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Compositions and methods for topical administration of pharmaceutically active agents

  • US 5,719,197 A
  • Filed: 06/07/1995
  • Issued: 02/17/1998
  • Est. Priority Date: 03/04/1988
  • Status: Expired due to Term
First Claim
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1. A flexible, finite, bioadhesive composition for topical application comprising:

  • (a) a therapeutically effective amount of at least one pharmaceutically active agent;

    (b) a pharmaceutically acceptable solvent for the pharmaceutically active agent and a plasticizer;

    (c) in admixture with the pharmaceutically active agent in the solvent, a pharmaceutically acceptable bioadhesive carrier in an amount from about 5 to 50 percent based on the weight of the whole composition; and

    (d) a cohesive increasing amount of a clay;

    wherein the composition is substantially free of water, substantially water insoluble and is a bioadhesive; and

    wherein the pharmaceutically active agent is present in non-crystallized form in the composition.

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