Peptide nucleic acids having amino acid side chains
First Claim
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1. A peptide nucleic acid having formula:
- ##STR3## wherein;
each L is independently a naturally-occurring nucleobase or a non-naturally-occurring nucleobase;
each R7'"'"' is independently hydrogen or C1 -C8 alkylamine, provided that at least one R7'"'"' is C1 -C8 alkylamine;
Rh is OH, NH2 or NHLysNH2 ;
Ri is H, COCH3 or t-butoxycarbonyl; and
n is an integer from 1 to 30.
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Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
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Citations
11 Claims
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1. A peptide nucleic acid having formula:
- ##STR3## wherein;
each L is independently a naturally-occurring nucleobase or a non-naturally-occurring nucleobase;each R7'"'"' is independently hydrogen or C1 -C8 alkylamine, provided that at least one R7'"'"' is C1 -C8 alkylamine; Rh is OH, NH2 or NHLysNH2 ; Ri is H, COCH3 or t-butoxycarbonyl; and n is an integer from 1 to 30. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- ##STR3## wherein;
Specification