Pacemaker with improved detection of atrial fibrillation

• US 5,720,295 A
• Filed: 10/15/1996
• Issued: 02/24/1998
• Est. Priority Date: 10/15/1996
• Status: Expired due to Term

• Current Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Greenhut, Saul E., Nappholz, Tibor A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/730,748
• Time in Patent Office: 497 Days
• Field of Search: 128/702, 128/704, 128/705, 607/4, 607/5, 607/9, 607/26
• US Class Current: 600/517
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

In a dual chamber implantable pacemaker, the peak amplitude of the atrial intrinsic signals are monitored and used to generate a short term and a long term indicia indicative of the intrinsic signals'"'"' variability and deviation from normal sinus rhythm peak amplitudes. The two indicia are combined to generate a single indicia which is then used to categorize the state of the atrium as one of several conditions such as flutter/flubber, coarse atrial fibrillation or fine atrial fibrillation. The categorization is used by a microcontroller for generating the proper pacing pulses and may also be used as a criteria for mode switching between a first mode wherein synchrony between the atrium and ventricle is maintained and a second mode pacing is performed at a fixed rate or one determined by the metabolic indicator.

Claims

1. An implantable pacemaker comprising:

at least one atrial sensor for sensing atrial signals;

a ventricular sensor for sensing ventricular signals;

a pacing generator for generating at least one of a ventricular and atrial pacing signals in accordance with a command signal;

an atrial processor receiving said atrial signals, said atrial processor including an analyzer for determining peak amplitudes of said atrial signals and a normal sinus rhythm value of said peak amplitudes, and for determining a change in a variability and deviation of said normal rhythm value, said atrial processor being further provided to detect new state of the atrium by analyzing said change in variability and deviation of said normal sinus rhythm value;

a controller receiving indication of said atrial and ventricular signals and said new atrial state and generating in response said command signal on the basis of said new atrial state.

2. The pacemaker of claim 1 wherein said analyzer further includes a categorizer for categorizing said new atrial state as one of a normal sinus rhythm, coarse fibrillation, fine fibrillation and flubber state.

3. The pacemaker of claim 2 further comprising a metabolic indicated rate parameter processor for generating a metabolic indicated rate parameter, said controller receiving said metabolic indicated rate parameter to modify an output of said categorizer.

4. The pacemaker of claim 2 wherein said atrial signals have a sinus rhythm and said analyzer includes a first portion for determining a short term variability and deviation of an amplitude of said atrial signals and a second portion for determining a long term variation of said atrial signals with respect to said sinus rhythm, said portions generating respective first and second indicia, said categorizer generating said atrial state based on a combination of said indicia.

5. The pacemaker of claim 4 wherein said analyzer includes a timer for defining sequential time periods, each period being partitioned into frames, wherein said first indicia is determined for each frame and said second indicia is determined for each period.

6. An implantable pacemaker comprising:

an atrial sensor for sensing atrial signals, said atrial signals having peak amplitudes and including sinus rhythm atrial signals and non-sinus rhythm atrial signals;

a ventricular sensor for sensing ventricular signals;

a first analyzer for determining a short term variability and deviation of said non-sinus rhythm signals from said sinus rhythm atrial signals and for generating a first indicia, said first indicia being dependent on said short term peak amplitude variability and deviation;

a second analyzer for determining a long term variability of said atrial signals and for generating a second indicia, said second indicia being dependent on said long term variability;

a categorizer for categorizing a new state of the atrium as a pathological state by combining said first and second indicia;

a pulse generator for generating atrial and ventricular pulses in response to a command signals; and

a controller for generating said command signals in response to said atrial and ventricular signals and said new state of the atrium.

7. The pacemaker of claim 6 further comprising a timer for generating sequential time periods, each time period being partitioned into several time frames, wherein each said first indicia is determined from atrial signals sensed during one of said frames, and each second indicia is determine during one of said periods.

8. The pacemaker of claim 6 further comprising a metabolic sensor for sensing a metabolic demand parameter, said controller generating said command signals in accordance with said metabolic demand parameter.

9. The pacemaker of claim 8 further including a mode switcher for switching said controller between a first mode in which said pulses are generated at a rate dependent on said metabolic rate parameter and a second mode in which said pulses are generated independently of said metabolic rate parameter.

10. The pacemaker of claim 9 wherein said mode switcher is activated by said new atrial state.

11. In an implantable pacemaker of the kind having atrial and ventricular sensors for sensing atrial and ventricular events and a pulse generator for generating atrial and ventricular events and a pulse generator for generating atrial and ventricular pulses on demand, a method of classifying cardiac arrhythmia from said atrial events comprising the steps of:

sensing a predetermined number of atrial events and generating corresponding atrial signals;

measuring an amplitude of each of said atrial signals;

determining a short term variability and deviation of said amplitudes;

determining a long term variability and deviation of said amplitudes;

generating a first indicative of said short term variability and deviation of said amplitudes;

generating a second indicia indicative of said long term variation and deviation of said amplitudes;

combining said first and second indicia into a third indicia; and

categorizing said cardiac arrhythmia in accordance with said third indicia.

12. The method of claim 11 further comprising the steps of:

defining a plurality of sequential periods, each period consisting of several frames;

measuring said first indicia during said frames; and

measuring said second indicia during said periods.

13. The method if claim 12 wherein each said period is about 12 seconds and each said frame is about 1.2 secs.

14. The method of claim 12 further comprising selecting said frames to include several cardiac cycles.

15. The method of claim 11 further comprising categorizing a cardiac state as being one of a flutter/flubber, coarse atrial fibrillation and fine atrial fibrillation.

16. The method of claim 11 further comprising the steps of:

generating a metabolic demand parameter after said step of categorizing; and

generating said pacing pulses at one of a first rate and a second rate wherein said first rate is related to said demand parameter and said second rate is a fixed rate independent of said demand parameter.

17. The method of claim 16 further comprising switching between said first and second rate in response to said categorization of said atrial state.