Method for estimating creatinine clearance using measurements of body cell mass

• US 5,722,396 A
• Filed: 08/13/1996
• Issued: 03/03/1998
• Est. Priority Date: 08/13/1996
• Status: Expired due to Fees

• Current Assignee: St Luke's-Roosevelt Hospital
• Original Assignee: St Luke's-Roosevelt Hospital Center (Sinai Health System)
• Inventors: Sordillo, Emilia M., Kotler, Donald P.
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/694,615
• Time in Patent Office: 567 Days
• Field of Search: 128/630, 128/734, 128/774, 128/898
• US Class Current: 600/547
• CPC Class Codes: G01N 33/493 urine
• CPC Class Codes: G01N 33/70 involving creatine or creatinine

Abstract

Creatinine clearance is estimated in a patient by determining his or her body cell mass. In turn, the body cell mass of the patient is measured using bioimpedance analysis techniques. The determined value of body cell mass is normalized by the height² of the patient. The body cell mass or its normalized value provides an indication of actual creatinine clearance in the subject through use of a predictive formula. From this prediction, accurate dosages of potentially nephrotoxic medications can be appropriately prescribed.

Claims

1. A method for estimating creatinine clearance in a subject, said method comprising the steps of:

calculating a value for body cell mass of said subject; and

estimating creatinine clearance of said subject as a function of said value.

2. The method of claim 1 wherein said calculating step includes the step of measuring said value using bioimpedance analysis.

3. The method of claim 1 further comprising the step of measuring the height of said subject.

4. The method of claim 3 wherein said predicting step comprises determining creatinine clearance according to the equation:

space="preserve" listing-type="equation">CL.sub.CR =12.5×

(BCMI)-5.7

where

CL_CR =creatinine clearance; and

BCMI=body cell mass (kg)/height² (m²).

5. A method for predicting creatinine clearance in a subject, said method comprising the steps of:

calculating the value of body cell mass of the subject using bioimpedance analysis;

measuring the height of said subject;

determining the body cell mass index of said subject; and

determining creatinine clearance according to the equation;

space="preserve" listing-type="equation">CL.sub.CR =12.5×

(BCMI)-5.7

where;

CL_CR =creatinine clearance; and

BCMI=body cell mass/height² (kg/m²).

6. The method of claim 5 wherein the calculating step includes the step of determining body cell mass according to the following equations:

space="preserve" listing-type="equation">BCM=0.76 (59.06)Ht.sup.1.60 /Xc.sub.p.sup.0.50 !+18.52(Wt)-386.66(for males);

space="preserve" listing-type="equation">or

space="preserve" listing-type="equation">BCM=0.96 (1.30)Ht.sup.2.07 /Xc.sub.p.sup.0.36 !+5.79(Wt)-230.51(for females);

where;

Ht=height (cm);

Xc_p =parallel transformed reactance (ohms); and

Wt=weight (kg).

7. A method for accurately prescribing medication comprising the steps of:

determining a value for the body cell mass of a subject;

determining a value for the height of the subject;

estimating creatinine clearance of said subject from said values of body cell mass and height; and

prescribing an appropriate dosage of medication in accordance with said estimated creatinine clearance.

8. The method of claim 7 wherein the step of determining said body cell mass comprises the step of using bioimpedance analysis.

9. The method of claim of claim 7 wherein said measuring of body cell mass comprises the following formulas to determine values for body cell mass:

space="preserve" listing-type="equation">BCM=0.76 (59.06)Ht.sup.1.60 /Xc.sub.p.sup.0.50 !+18.52(Wt)-386.66(for males);

space="preserve" listing-type="equation">or

space="preserve" listing-type="equation">BCM 32 0.96 (1.30)Ht.sup.2.07 /Xc.sub.p.sup.0.36 !+5.79(Wt)-230.51(for females);

where;

Ht=height (cm);

Xc_p =parallel transformed reactance (ohms); and

Wt=weight (kg).

10. The method of claim 7 wherein the step of estimating the creatinine clearance of said subject comprises using the following formula:

space="preserve" listing-type="equation">CL.sub.CR =12.5×

(BCMI)-5.7

where;

CL_CR =creatinine clearance; and

BCMI=body cell mass/height² (kg/m²).