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Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers

  • US 5,722,397 A
  • Filed: 06/06/1995
  • Issued: 03/03/1998
  • Est. Priority Date: 11/15/1993
  • Status: Expired due to Term
First Claim
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1. A portable device attachable to a selected area of an individual'"'"'s body surface for monitoring concentrations of an analyte in the body comprising(a) a collection unit including(I) reservoir means for holding a chemical permeation enhancer for delivery to the body surface and receiving analyte from the body surface;

  • (ii) a source optical fiber, couplable to a light source, for conducting light energy therethrough and emitting evanescent wave energy; and

    (iii) a detection optical fiber, couplable to a detection device, for capturing and conducting evanescent wave energy, wherein the source and detection optical fibers each have a surface with a binder disposed thereon for binding the analyte; and

    (b) an electronic unit releasably coupleted to the collection unit including(I) an ultrasound transducer for enhancing permeation of the analyte out of the individual'"'"'s body into the reservoir means, the transducer disposed such that when the device is disposed on a selected area of an individual'"'"'s body surface the reservoir is between the body surface and the transducer;

    (ii) a power source coupled to the transducer;

    (iii) a light source coupled to the power source and releasably coupleted to the source optical fiber for providing light energy to the source optical fiber;

    (iv) a detection device releasably coupled to the detection optical fiber for receiving and measuring evanescent wave energy therefrom;

    (v) an electronic circuit coupled to the transducer, power source, light source, detection device, and an output device, for controlling the operation of the transducer and light source, receiving measurements of light from the detection device, determining parameters of an equilibrium curve, calculating analyte concentration in the body from the equilibrium curve, and sending a signal containing the analyte concentration to the output device;

    (vi) an output device for receiving the signal containing the analyte concentration and displaying the analyte concentration; and

    (vii) a cover for enclosing and protecting the transducer, power supply, light source, detection device, electronic circuit, and output device, wherein the cover contains an opening through which the output device displays information.

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