Method for remote delivery of an aerosolized liquid

• US 5,722,950 A
• Filed: 06/07/1995
• Issued: 03/03/1998
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Tolmar Therapeutics, Inc. (TOLMAR Holding, Inc.)
• Original Assignee: Atrix Laboratories, Inc. (TOLMAR Holding, Inc.)
• Inventors: Southard, Jeffrey L., Fujita, Shawn M.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/476,796
• Time in Patent Office: 1,000 Days
• Field of Search: 604/82, 604/19, 604/48, 604/73, 604/131, 604/140, 239/341, 239/346, 222/173, 222/137, 222/81
• US Class Current: 604/48
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069

Abstract

The invention provides an apparatus for remote delivery of an aerosolized liquid by laparoscopic technique, a method of delivering an aerosolized liquid into the body of an animal by means of the apparatus, and a kit that contains components of the apparatus.

Claims

1. A method of applying an aerosol into the body of an animal, comprising:

(a) providing an apparatus having an air and fluid dispensing gun housing, a tubular extension rod housing adapted for laparoscopic administration, the tubular extension rod housing having a first end, a second end, an air channel and a fluid channel, each of said channels extending the length through the extension rod housing;

said apparatus being connected to an external source of air and an external source of liquid; and

(b) inserting the extension rod housing of said apparatus into the animal;

wherein the liquid is drawn into the fluid channels and dispensed from the second end of the extension rod to form an aerosol that is dispensed into the body of the animal.

2. The method of claim 1, wherein the liquid comprises a biologically-active agent in combination with a pharmaceutically-acceptable carrier.

3. The method of claim 1, wherein the liquid comprises a biodegradable, water-insoluble thermoplastic polymer or copolymer and a water-miscible or water-dispersible organic solvent.

4. The method of claim 3, wherein the aerosol coats a tissue or organ and forms a film thereon.

5. The method of claim 3, wherein the liquid further comprises a biologically-active agent.