Antithrombogenic radioactive coating for an intravascular stent

• US 5,722,984 A
• Filed: 01/16/1996
• Issued: 03/03/1998
• Est. Priority Date: 01/16/1996
• Status: Expired due to Fees

• Current Assignee: Isostent, Inc. (Cardinal Health, Inc.)
• Original Assignee: ISO Stent Incorporated
• Inventors: Fischell, David R., Fischell, Tim A.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): Lewis, William W.
• Application Number:
  US08/585,760
• Time in Patent Office: 777 Days
• Field of Search: 606/1, 606/108, 606/191-198, 606/200, 600/3, 600/12, 128/898, 128/899
• US Class Current: 606/198
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/44 Radioisotopes, radionuclides
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

Disclosed is a coating material which has both antithrombogenic properties and contains an embedded radioisotope that makes the coating material radioactive As phosphorous 32 is emerging as the preferred isotope for vascular radioisotope stents, and phosphorylcholine has shown promise as an antithrombogenic stent coating, it is envisioned here to produce a stent with a phosphorylcholine coating with some of the phosphorous in the coating being phosphorous 32 rather than the naturally occurring, non-radioactive element phosphorous 31. In this manner one has a stent which has a single stent coating which is both antithrombogenic and radioactive. The stent could also utilize an inner layer which is both antithrombogenic and radioactive and an outer layer which is only antithrombogenic. A preferred embodiment of the invention is to produce a phosphorylcholine coated stent where some of the phosphate groups contain the radioisotope phosphorous 32.

Claims

1. An intravascular stent comprising:

a thin, wire-like, generally cylindrical metal structure, the stent having a single layered coating of the metal structure which single layered coating is both antithrombogenic and radioactive.

2. The stent of claim 1 wherein the single layered comprising material that includes the molecule phosphorylcholine and at least some of the phosphorous atoms in phosphorylcholine molecule are phosphorous 32.