Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds
First Claim
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1. A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of:
- (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound, wherein the skin parameters include at least one member selected from the group consisting of melanin, non-melanin chromophores, skin thickness, water content, fat content, temperature, blood flow, skin quality, skin elasticity, hair follicles, sebaceous glands, permeability, proteins, and amino acids, and wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation.
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Abstract
A process of calibrating an individual in preparation for the non-invasive measurement of an biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).
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10 Claims
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1. A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of:
(a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound, wherein the skin parameters include at least one member selected from the group consisting of melanin, non-melanin chromophores, skin thickness, water content, fat content, temperature, blood flow, skin quality, skin elasticity, hair follicles, sebaceous glands, permeability, proteins, and amino acids, and wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation. - View Dependent Claims (2, 3, 4, 5, 9, 10)
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6. A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of:
(a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound wherein the skin parameter is melanin, wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation, and wherein the contribution of melanin to the absorption and transmittance of non-ionizing radiation is accomplished by determining the absorption and scattering coefficients of melanin. - View Dependent Claims (7, 8)
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