Extracorporeal circulation apparatus and method
First Claim
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1. An extracorporeal blood circulation apparatus comprising circuitry including:
- (a) an inlet line adapted to receive blood from a patient,(b) an outlet line adapted to return blood to the patient,(c) a fluid circuit for fluid communication between the inlet and the outlet line,(d) at least one pump acting on the fluid circuit to circulate blood therethrough and out the outlet line, and(e) one or more nitric oxide gas feeds to said fluid circuit, at least one being upstream of said pump,(f) a container comprising a source of nitric oxide connected to one or more nitric oxide gas feeds.
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Abstract
Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.
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Citations
13 Claims
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1. An extracorporeal blood circulation apparatus comprising circuitry including:
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(a) an inlet line adapted to receive blood from a patient, (b) an outlet line adapted to return blood to the patient, (c) a fluid circuit for fluid communication between the inlet and the outlet line, (d) at least one pump acting on the fluid circuit to circulate blood therethrough and out the outlet line, and (e) one or more nitric oxide gas feeds to said fluid circuit, at least one being upstream of said pump, (f) a container comprising a source of nitric oxide connected to one or more nitric oxide gas feeds.
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2. An extracorporeal blood circulation apparatus comprising circuitry including:
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(a) an inlet line adapted to receive blood from a patient, (b) an outlet line adapted to return blood to the patient, (c) a fluid circuit for fluid communication between the inlet and the outlet line said fluid circuit including a blood treatment portion, (d) one or more nitric oxide gas feeds to said fluid circuit, at least one being upstream of at least said blood treatment portion, and, (e) one or more nitric oxide gas feeds to said fluid circuit, at least one being upstream of at least said blood treatment portion, and (f) a container comprising a source of nitric oxide connected to one or more nitric oxide gas feeds. - View Dependent Claims (3, 4, 5, 6)
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- 7. In a cardiopulmonary bypass apparatus comprising circuitry including an inlet line adapted to receive blood from a patient and an outlet line adapted to return blood to the patient, a reservoir connected to the inlet line for accumulation of blood received from the patient, an oxygenator, a fluid interconnection circuit for fluid communication between the reservoir and the oxygenator and between the oxygenator and the outlet line, and at least one pump acting on the fluid circuit to withdraw blood from the reservoir and circulate it through the oxygenator and out the outlet line, the improvement which comprises one or more nitric oxide gas feeds to the circuitry, at least one being upstream of the oxygenator, and a container comprising a source of nitric oxide connected to one or more nitric oxide gas feeds.
Specification