Containers for liquid medicaments

• US 5,725,500 A
• Filed: 05/23/1996
• Issued: 03/10/1998
• Est. Priority Date: 06/02/1995
• Status: Expired due to Term

• Current Assignee: Clemens Micheler
• Original Assignee: Eli Lilly and Company
• Inventors: Micheler, Clemens
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/652,078
• Time in Patent Office: 656 Days
• Field of Search: 604/89, 604/82, 604/90, 604/91, 604/191, 604/218, 604/903, 366/241, 366/244, 366/267, 366/342, 366/343, 366/130, 366/273
• US Class Current: 604/82
• CPC Class Codes: A61J 1/062 Carpules
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: B01F 31/24 the containers being submitted to a rectilinear movement
• CPC Class Codes: B01F 31/441 performing a rectilinear reciprocating movement
• CPC Class Codes: B01F 33/25 Mixers with loose mixing elements, e.g. loose balls in a receptacle
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 35/3202 Hand driven
• CPC Class Codes: B01F 35/32021 Shaking by hand a portable receptacle or stirrer for mixing
• CPC Class Codes: Y10S 604/903 Medical container with material agitation means

Abstract

A container for a liquid medicament suspension, e.g. an insulin crystal suspension, has a tube with a sealing piston, a cap, and a mixing element which moves along the tube to assist mixing the suspension. The element is guided by the inner surface of the tube and has restricted lateral movement but is free to move axially, for example, by tilting or end to end inversion of the container. Flow passages such as apertures and peripheral recesses are provided in the mixing element which can serve to promote turbulent flow.

The containers are particularly suited for use as multi-dose cartridges for pen-like injection devices or for portable infusion devices which have piston-operating mechanisms to cooperate with the container piston.

Claims

1. A container for a liquid medicament suspension having a piston operable therein and an outlet therefrom, and containing a solid mixing element, wherein the mixing element and the inner surface of the container are shaped to co-operate and constrain the mixing element against significant lateral movement but permit axial movement, the mixing element being shaped to permit flow of suspension from either side of the element to the other as the element moves axially.

2. A container as claimed in claim 1, wherein the mixing element is shaped so as to present and define a plurality of angularly spaced-apart regions for co-operation with the inner surface of the container.

3. A container as claimed in claim 1, wherein the mixing element is constrained against significant lateral movement within the container by being dimensioned so as to be in a close but sliding fit within the container.

4. A container as claimed in claim 1, wherein the mixing element is free to rotate axially.

5. A container as claimed in claim 1, wherein the mixing element, in order to permit flow of suspension from either side of the element to the other, is provided with means defining one or more apertures extending through the element, and/or with one or more passages defined by the element in combination with the inner surface of the container.

6. A container as claimed in claim 5, wherein the passages are partly defined by recesses or channels formed in the periphery of the element.

7. A container as claimed in claim 6, wherein the apertures, recesses or channels are profiled with projections or constrictions to increase turbulence in the suspension as the suspension flows from either side of the mixing element to the other.

8. A container as claimed in claim 7, wherein the apertures, recesses or channels are angularly disposed relative to the axis of the mixing element so as to impart an axial rotary motion to the element as it moves axially within the container.

9. A container as claimed in claim 1, wherein the container and the inner surface thereof is cylindrical and the overall transverse cross-section of the mixing element is circular.

10. A container as claimed in claim 1, wherein the mixing element is made of metal, ceramic, plastics material or glass.

11. A container as claimed in claim 1, wherein the mixing element is buoyant in the suspension medium.

12. A container as claimed in claim 1, wherein the mixing element is caused to move axially within the container, by the action of tilting or end to end inversion of the container.