Injection devices

• US 5,728,075 A
• Filed: 08/14/1995
• Issued: 03/17/1998
• Est. Priority Date: 10/29/1993
• Status: Expired due to Term

• Current Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Original Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Inventors: Levander, Gustav
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): NGUYEN, ANH TUAN TUONG
• Application Number:
  US08/464,875
• Time in Patent Office: 946 Days
• Field of Search: 604/211, 604/187, 604/224, 604/228, 604/82, 604/89, 604/90, 604/91, 604/218, 604/232, 604/241, 604/207, 604/208, 604/210
• US Class Current: 604/211
• CPC Class Codes: A61M 2005/31508 provided on the piston-rod
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Abstract

A piston rod device for use in an injection device for an injection cartridge is provided with a single or multiple thread (3) along a predetermined portion of its length, after which the thread (3) changes into a longitudinal groove (5) for each thread, such that a turning movement of the piston rod will turn into an axial movement after the predetermined length. The thread (3) is shaped as one or more helicoidal grooves in the surface of the piston rod (1), the grooves (3) turning into longitudinal grooves (5) after the predetermined length. A nut element (6) cooperates with the thread (3), and its device for cooperating consists of at least one radial inwardly directed projection (10) for each thread, the projection (10) or projections guiding the piston rod (1) by the groove or grooves forming the thread (3).

Claims

1. A device for use in an injection device for a dual-chamber or multi-chamber injection cartridge, wherein said device comprises a cartridge having a front chamber and a rear chamber separated by an intermediate movable wall, said front chamber being adapted for holding a solid component of an injection preparation and said rear chamber being adapted for holding a liquid component of said preparation;

said cartridge further includes an interior wall and has arranged in said interior wall a bypass connection for permitting the liquid to flow around and bypass said intermediate movable wall for mixing with the solid component; and

wherein said device further comprises a piston rod having a single or multiple thread along a predetermined length thereof, and a nut element which cooperates with said thread and being adapted for applying pressure through the liquid in said rear chamber for also urging said intermediate movable wall forward to position it at said bypass connection thereby making it possible for the liquid component to bypass said intermediate movable wall and flow in said front chamber to be mixed with the solid component; and

wherein further forward pressure on said piston rod moves it together with said intermediate movable wall for expelling the injectable preparation from said front chamber through an outlet conduit in the front chamber;

wherein said thread on the piston rod is shaped as at least one helicoidal groove in the surface of said piston rod, each groove after the predetermined length turning into a longitudinal groove in said surface, such that a helicoidal movement of said piston rod for said predetermined length is changed into a linear movement in the longitudinal direction, and that the device in the nut element for cooperating with said thread consists of at least one inwardly directed radial projection for each thread, said projection or projections guiding said piston rod by the groove or grooves forming said thread.

2. A device according to claim 1 characterized in that the external diameter of the piston rod is adapted to the internal diameter of the nut element such that the piston rod fits slidably in the nut element without any substantial radial play.

3. A device according to claim 1 characterized in that the piston rod is provided with a double thread and that the nut element is provided with two corresponding, inwardly directed radial projections, which are evenly spaced along the internal circumference of said nut element.

4. A device according to claim 1 characterized in that the piston rod is provided with a triple thread and that the nut element is provided with three corresponding, inwardly directed radial projections, which are evenly spaced along the internal circumference of said nut element.

5. A device according to claim 1 characterized in that the groove or grooves in the piston rod have a trapezoidal or triangular cross-section.

6. A device according to claim 1, wherein the threads of the piston rod are arranged as a snap lock mechanism, which cooperates with the projection or projections in the nut element.