Expandable microporous prosthesis
First Claim
1. A method of minimizing roll bias in a self-expandable tubular prosthesis, comprising the steps of:
- providing a flexible sheet;
creating at least a first and a second group of apertures through the sheet; and
rolling the sheet about a longitudinal axis to form a self expandable tubular prosthesis;
wherein the first group of apertures induces a roll bias component in a first direction along the longitudinal axis, and the second group of apertures induces a roll bias component in a second, opposite direction along the longitudinal axis to minimize any net roll bias in the tubular prosthesis.
1 Assignment
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Accused Products
Abstract
Disclosed is a tubular prosthesis formed by rolling a perforated sheet around a longitudinal axis. Preferably, the prosthesis is self expandable under the radially outwardly directed spring bias of the rolled sheet. The perforations in the sheet are configured to provide throughholes in the wall of the multilayer prosthesis, when the prosthesis is in the implanted diameter within a vessel. The throughholes are configured to facilitate neointimal cell growth, and in a preferred embodiment, to minimize roll bias in the prosthesis as it is expanded from its reduced, insertion diameter to its expanded, implanted diameter. The prosthesis may be used as a graft or a stent.
388 Citations
26 Claims
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1. A method of minimizing roll bias in a self-expandable tubular prosthesis, comprising the steps of:
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providing a flexible sheet; creating at least a first and a second group of apertures through the sheet; and rolling the sheet about a longitudinal axis to form a self expandable tubular prosthesis; wherein the first group of apertures induces a roll bias component in a first direction along the longitudinal axis, and the second group of apertures induces a roll bias component in a second, opposite direction along the longitudinal axis to minimize any net roll bias in the tubular prosthesis.
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2. A tubular prosthesis, comprising:
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a flexible rectangular sheet, having a longitudinal axis and at least first, second, and third groups of apertures extending therethrough; the first group comprising a first plurality of parallel slots inclined at a first angle with respect to the longitudinal axis; the second group comprising a second plurality of parallel slots inclined at a second angle with respect to the longitudinal axis; the first, second, and third groups of apertures arranged on the sheet such that when the sheet is wrapped about an axis through at least about three revolutions to form a tubular prosthesis, apertures from the first, second, and third groups align to produce a plurality of ports extending through the side wall of the prosthesis.
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3. An intraluminal stent implantable in a body vessel lumen, comprising:
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a tubular body having a side wall and an inner lumen with an axial length extending between first and second ends of the tubular body, said tubular body formed of a sheet of bio-compatible material forming said side wall and inner lumen when placed in the vessel lumen in an expanded roll state, said sheet having a sheet length providing said first and second overlapping layers when said sheet is in the expanded roll state and a sheet width corresponding to said axial length; and first and second perforation zones formed in first and second portions of said sheet displaced from one another along said sheet length, said first perforation zone having a first plurality of elongated perforations extending in parallel with one another in a first direction, and said second perforation zone having a second plurality of elongated perforations extending in parallel with one another in a second direction differing from said first direction; wherein the first and second perforation zones substantially overlap one another when said sheet is rolled up into said tubular body having at least two layers in the vessel lumen and provide openings in said side wall through aligned portions of said elongated perforations. - View Dependent Claims (4, 5, 6, 7, 8)
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9. In an intraluminal stem implantable in a body vessel lumen of the type comprising a tubular body having a side wall and an inner lumen of an axial length extending between first and second ends, said tubular body formed of a sheet of biocompatible material rolled into a plurality of layers to form said side wall and inner lumen, said sheet having a sheet length providing said plurality of overlapping layers when said sheet is rolled up in the direction of the sheet length and a sheet width corresponding to said axial length, the improvement comprising:
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means for defining first and second rows extending substantially across said sheet width and along said sheet length; in said first row, first and second perforation zones formed in first and second portions of said sheet displaced from one another along said sheet length, said first perforation zone of said first row having a first plurality of elongated perforations extending in parallel with one another in a first direction in said first row, and said second perforation zone of said first row having a second plurality of elongated perforations extending in parallel with one another in a second direction in said first row; in said second row, first and second perforation zones formed in further first and second portions of said sheet displaced from one another along said sheet length in side-by-side relation to said first and second perforation zones in said first row, said first perforation zone of said second row having a first plurality of elongated perforations extending in parallel with one another in a first direction of said second row, and said second perforation zone of said second row having a second plurality of elongated perforations extending in parallel with one another in a second direction of said second row, such that; said first and second perforation zones of said first row substantially overlap one another when said sheet is rolled up into said tubular body and provide openings through said side wall at aligned portions of said elongated perforations; and said first and second perforation zones of said second row substantially overlap one another when said sheet is rolled up into said tubular body and provide openings through said side wall at aligned portions of said elongated perforations. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. An intraluminal stem adapted to be introduced to a site in a body vessel in a collapsed roll state and implanted to bridge the site in an expanded roll state, the stent comprising:
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a tubular body having a side wail and an inner lumen of an axial length extending in a longitudinal direction between first and second ends, the tubular body formed of a sheet of biocompatible material rolled into a plurality of overlapping layers to form the tubular body side wail and inner lumen, the sheet having a sheet width corresponding to the tubular body axial length and a sheet length providing the plurality of overlapping layers when in the expanded roll state; a plurality of perforation zones formed in the sheet and spaced apart along the sheet length adapted to substantially overlie one another when the sheet is rolled into the plurality of layers in the expanded roll state, the perforation zones occupying substantially equal areas of the sheet; and each perforation zone further comprising a plurality of elongated perforations extending in parallel with one another at a predetermined perforation angle to the sheet length, wherein the perforation angle of the elongated perforations at each perforation zone differs from the perforation angle of the elongated perforations of other perforation zones along the sheet length, whereby the plurality of perforation zones substantially overlie one another when the sheet is rolled in the expanded roll state having a substantially corresponding plurality of sheet layers forming the tubular body side wall and provide holes extending through the tubular body side wall where portions of the elongated perforations in the perforation zone in each layer are aligned with one another to encourage the formation of neointimal growth in the tubular body lumen between the adjacent holes. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification