Skin treatment with salicylic acid esters and retinoids

• US 5,728,732 A
• Filed: 11/27/1996
• Issued: 03/17/1998
• Est. Priority Date: 11/27/1996
• Status: Expired due to Term

• Current Assignee: FD Management, Inc. (Elizabeth Arden (Financing), Inc.)
• Original Assignee: Elizabeth Arden Company Division of Conopco Incorporated
• Inventors: Corey, Joseph Michael, Guerrero, Angel Augusto
• Primary Examiner(s): Cook, Rebecca
• Application Number:
  US08/757,784
• Time in Patent Office: 475 Days
• Field of Search: 514/544, 514/725, 514/546, 514/549
• US Class Current: 514/544
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 5/006 Antidandruff preparations

Abstract

A method and composition is provided for treating skin conditions including those arising from dermatologic disorders, chronoaging and environmental abuse. Non-ring esterified C₁₁ -C₃₀ alkyl or alkenyl esters of salicylic acid in combination with a retinol C₁₈ -C₃₀ fatty acid ester used as the active components are applied to the skin in a pharmaceutically acceptable carrier. Most preferred as the salicylate ester is tridecyl salicylate and as the retinol fatty acid ester is retinyl linoleate.

Claims

1. A cosmetic composition comprising:

(i) a safe and effective amount of a salicylate ester having formula (I);

##STR4## wherein R is a C₁₁ -C₃₀ alkyl or alkenyl radical;

(ii) a safe and effective amount of a retinol C₁₈ -C₃₀ fatty acid ester; and

(iii) a safe and effective amount of a pharmaceutically acceptable carrier.

2. The cosmetic composition according to claim 1 wherein the salicylate ester is a C₁₂ -C₂₀ alkyl ester of salicylic acid.

3. The cosmetic composition according to claim 1 wherein the salicylate ester is tridecyl salicylate.

4. The cosmetic composition according to claim 1 wherein the retinol fatty acid ester is retinyl linoleate.

5. A method for treating skin conditions selected from the group consisting of acne, dry skin, dandruff, keratosis, pruritus, inflammatory dermatitis, eczema, psoriasis, tinea pedis, wrinkling, leatheriness, yellowing, sagging, mottling and age spots, the method comprising applying to the skin a safe and effective amount of a combination of a retinol C₁₈ -C₃₀ fatty acid ester and a salicylate ester, the salicylate ester having the formula (I):

##STR5## wherein R is a C₁₁ -C₃₀ alkyl or alkenyl radical.

6. The method of claim 5 wherein the skin conditions are selected from the group consisting of acne, dry skin, dandruff, keratosis, pruritus, inflammatory dermatitis, eczema, psoriasis and tinea pedis.

7. The method according to claim 5 wherein the skin conditions are selected from the group consisting of wrinkling, leatheriness, yellowing, sagging, and age spots.

8. The method according to claim 5 wherein R is a C₁₂ -C₂₀ alkyl or alkenyl group.

9. The method according to claim 5 wherein the salicylate ester is tridecyl salicylate.

10. The method according to claim 5 wherein the retinol fatty acid ester is retinyl linoleate.