Antiplaque antibacterial oral composition

• US 5,728,756 A
• Filed: 06/24/1996
• Issued: 03/17/1998
• Est. Priority Date: 01/30/1987
• Status: Expired due to Fees

• Current Assignee: Crane Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Nabi, Nuran, Stringer, Orum, Gaffar, Abdul, Afflitto, John
• Primary Examiner(s): Cintins, Marianne M.
• Assistant Examiner(s): JONES, DWAYNE C
• Application Number:
  US08/668,754
• Time in Patent Office: 631 Days
• Field of Search: 524/139, 524/136, 524/130, 424/52
• US Class Current: 524/139
• CPC Class Codes: A61K 2800/87 Application Devices; Containers; Packaging
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/81 obtained by reactions involving only carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61K 8/8164 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C08F 230/02 containing phosphorus

Abstract

An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'"'"'-trichloro-2'"'"'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methy cellosolve and ethyl cellosolve: a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.

Claims

1. Beta styrene phosphonic acid/vinyl phosphonic acid copolymer, said copolymer being water-soluble and having a molecular weight of about 2,000 to about 30,000.

2. A method of preparing a polymer as defined in claim 1 comprising polymerizing the precursor mixture of monomers at elevated temperatures in the presence of a radical initiator, mixing the crude polymeric product with water, adjusting the resulting solution of pH of about 8-11, dialyzing the solution against water and isolating the purified copolymer therefrom.