Antibodies directed against elk ligand

• US 5,728,813 A
• Filed: 11/12/1996
• Issued: 03/17/1998
• Est. Priority Date: 11/13/1992
• Status: Expired due to Fees

• Current Assignee: Immunex Corporation (Amgen Inc.)
• Original Assignee: Immunex Corporation (Amgen Inc.)
• Inventors: Baum, Peter R., Lyman, Stewart, Beckmann, M. Patricia
• Primary Examiner(s): Walsh, Stephen
• Assistant Examiner(s): Spector, Lorraine
• Application Number:
  US08/747,240
• Time in Patent Office: 490 Days
• Field of Search: 530/387.9, 530/388.23, 530/350, 435/69.1, 435/325, 435/331, 435/335, 424/139.1
• US Class Current: 530/387.9
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/52 Cytokines; Lymphokines; Interferons
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748
• CPC Class Codes: C07K 16/24 against cytokines, lymphokines or interferons
• CPC Class Codes: C07K 19/00 Hybrid peptides , i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
• CPC Class Codes: C07K 2317/34 Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
• CPC Class Codes: C07K 2319/00 Fusion polypeptide
• CPC Class Codes: C07K 2319/02 containing a signal sequence
• CPC Class Codes: C07K 2319/30 Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
• CPC Class Codes: C07K 2319/32 fusions with soluble part of a cell surface receptor, "decoy receptors"
• CPC Class Codes: Y10S 930/14 Lymphokine; related peptides

Abstract

Antibodies to elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.

Claims

1. An antibody that is immunoreactive with an elk ligand (elk-L) polypeptide, wherein the elk-L polypeptide which consists of the amino acid sequence of residues 1 to 322 of SEQ ID NO:

2.

2. An antibody according to claim 1, wherein said antibody is a monoclonal antibody.

3. An antibody that is immunoreactive with an elk-L polypeptide, wherein the elk-L polypeptide which consists of the amino acid sequence of residues 1 to 213 of SEQ ID NO:

2.

4. An antibody according to claim 3, wherein said antibody is a monoclonal antibody.