Method and apparatus for detecting tachycardia

• US 5,730,142 A
• Filed: 03/21/1997
• Issued: 03/24/1998
• Est. Priority Date: 12/04/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Panken, Eric J., Combs, William J., Sun, Weimin
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/821,486
• Time in Patent Office: 368 Days
• Field of Search: 128/705
• US Class Current: 600/578
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A method and apparatus for detecting tachycardia in a patient employs a digitally-sampled electrocardiographic signal input to a digital processor employing a Hidden Markov Modeling algorithm to eliminate confusion between far-field and near-field cardiac events to provide a more accurate measurement of cardiac rate for diagnosis and treatment.

Claims

1. A method of determining an atrial tachycardia by ensuring that atrial sense events result from intrinsic P-waves originating in the atria and are not far field R-waves comprising the steps of:

sensing the atrial electrocardiogram from at least one electrode positioned in sensing relation to the patient'"'"'s atria;

detecting an atrial sense event comprising one of the P-wave or far field R-wave in the atrial electrogram;

sensing the ventricular electrogram from at least one electrode positioned in sensing relation to the patient'"'"'s ventricle;

detecting a ventricular sense event comprising the R-wave in the ventricular electrogram;

determining the end of each cardiac cycle from successive ventricular sense events;

during each cardiac cycle, discriminating intrinsic P-waves from far field R-waves in the atrial electrogram using Hidden Markov Modeling (HMM), wherein the P-wave and far-field R-wave can each be characterized as a state separated by state transitions in a hidden state sequence and wherein there are discrete probabilities that the states will transition from one to the other in a predetermined order; and

based on the HMM discrimination of the atrial sense events as intrinsic P-waves or far field R-waves and the timed intervals between intrinsic P-waves in the cardiac cycles, determining the existence of an atrial tachycardia.

2. The method of claim 1, wherein the HMM discrimination step further comprises the steps of:

continuously sampling the sensed atrial electrogram at a predetermined sampling rate and providing an atrial sense sample value at each sample time;

framing a sample data set of m atrial sense sample values as a data frame in response to the detection of an event of interest;

wavelet transforming the data frame of m atrial sense sample values to generate m wavelet transformed coefficients;

selecting C_W wavelet coefficients from among the m wavelet coefficients representing an observation vector correlated to each data frame;

retaining the observation vectors correlated to each data frame through the end of the cardiac cycle;

upon determining the end of the cardiac cycle, applying the HMM algorithm to each observation vector retained until the end of the cardiac cycle to generate the hidden state sequence; and

from the hidden state sequence, determining the sequence of intrinsic P-waves and far field R-waves in the atrial electrogram in the preceding heart cycle.

3. Apparatus for determining an atrial tachycardia by ensuring that atrial sense events result from intrinsic P-waves originating in the atria and are not far field R-waves comprising:

means for sensing the atrial electrocardiogram from at least one electrode positioned in sensing relation to the patient'"'"'s atria;

means for detecting an atrial sense event comprising one of the P-wave or far field R-wave in the atrial electrogram;

means for sensing the ventricular electrogram from at least one electrode positioned in sensing relation to the patient'"'"'s ventricle;

means for detecting a ventricular sense event comprising the R-wave in the ventricular electrogram;

means for determining the end of each cardiac cycle from successive ventricular sense events;

means operable during each cardiac cycle for discriminating intrinsic P-waves from far field R-waves in the atrial electrogram using Hidden Markov Modeling (HMM), wherein the P-wave and far-field R-wave can each be characterized as a state separated by state transitions in a hidden state sequence and wherein there are discrete probabilities that the states will transition from one to the other in a predetermined order; and

means for determining the existance of an atrial tachyarrhythmia based on the HMM discrimination of the atrial sense events as intrinsic P-waves or far field R-waves and the timed intervals between intrinsic P-waves in the cardiac cycles.

4. The apparatus of claim 3, wherein the HMM discrimination means further comprises:

means for continuously sampling the sensed atrial electrogram at a predetermined sampling rate and providing an atrial sense sample value at each sample time;

means for framing a sample data set of m atrial sense sample values as a data frame in response to the defection of an event of interest;

means for wavelet transforming the data frame of m atrial sense sample values to generate m wavelet transformed coefficients;

means for selecting C_W wavelet coefficients from among the m wavelet coefficients representing an observation vector correlated to each data frame;

means for retaining the observation vectors correlated to each data frame through the end of the cardiac cycle;

means for applying the HMM algorithm to each observation vector retained until the end of the cardiac cycle to generate the hidden state sequence upon determining the end of the cardiac cycle; and

means for determining the sequence of intrinsic P-waves and far field R-waves in the atrial electrogram in the preceding heart cycle from the hidden state sequence.