Compositions containing contortrostatin and methods for the use thereof

• US 5,731,288 A
• Filed: 04/15/1996
• Issued: 03/24/1998
• Est. Priority Date: 10/22/1993
• Status: Expired due to Term

• Current Assignee: University of Southern California
• Original Assignee: University of Southern California
• Inventors: Trikha, Mohit, Markland, Francis S. Jr., Lucchesi, Benedict R.
• Primary Examiner(s): Tsang, Cecilia J.
• Assistant Examiner(s): Gupta, Anish
• Application Number:
  US08/632,691
• Time in Patent Office: 708 Days
• Field of Search: 514/12, 530/324
• US Class Current: 424/94.63
• CPC Class Codes: A61K 38/1703 from vertebrates
• CPC Class Codes: C07K 14/46 from vertebrates

Abstract

Contortrostatin is employed as active agent for treatment of thrombotic disease. Preferably, contortrostatin is employed in conjunction with at least one thrombolytic agent. In addition, contortrostatin is useful in compositions and methods for preventing metastases in carcinoma and melanoma patients, treating or preventing osteoporosis and promoting wound healing.

Claims

1. In a method of treating thrombotic disease wherein at least one thrombolytic agent is administered in an amount effective to lyse thrombi, the improvement comprising administering to a patient in need of such treatment contortrostatin in an amount effective to prevent thrombus formation.

2. A method according to claim 1, wherein contortrostatin is administered in an amount within the range of about 0.01 mg/kg to about 50 mg/kg per day.

3. A method according to claim 1, wherein contortrostatin is administered in an amount within the range of about 0.1 mg/kg to about 5 mg/kg per day.

4. A method according to claim 1, wherein contortrostatin is administered in an amount within the range of about 0.1 mg/kg to about 0.5 mg/kg per day.

5. A method according to claim 1, wherein said thrombolytic agent is selected from the group consisting of anisoylated plasminogen streptokinase activator complex, tissue-type plasminogen activator, urokinase-type plasminogen activator and fibrolase.

6. A composition for treatment of thrombotic disease in a mammal, comprising contortrostatin in an amount effective to prevent thrombus formation and a suitable carrier or excipient.

8. A composition according to claim 6, wherein said thrombolytic agent is selected from the group consisting of anisoylated plasminogen streptokinase activator complex, tissue-type plasminogen activator, urokinase-type plasminogen activator and fibrolase.

7. A composition for treatment of thrombotic disease in a mammal, comprising contortrostatin in an amount effective to prevent thrombus formation, at least one thrombolytic agent in an amount effective to lyse thrombi and a suitable carrier or excipient.