Derivatives of camptothecin and methods of treating cancer using these derivatives
First Claim
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1. A compound of formula (I):
- ##STR7## wherein R1 is a C1 -C15 alkyl group, a C2 -C15 alkenyl group or a C2 -C15 epoxidized alkenyl group and R2 is NO2.
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Abstract
Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R2 is H, R1 is a C2 -C15 alkyl group, a C2 -C15 alkenyl group or an epoxy group; and when R2 is a nitro group, R1 is a C1 -C15 alkyl group, a C1 -C15 alkenyl group or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
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Citations
17 Claims
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1. A compound of formula (I):
- ##STR7## wherein R1 is a C1 -C15 alkyl group, a C2 -C15 alkenyl group or a C2 -C15 epoxidized alkenyl group and R2 is NO2.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
Specification