Stilbene derivatives and pharmaceutical compositions containing them

• US 5,731,353 A
• Filed: 03/08/1996
• Issued: 03/24/1998
• Est. Priority Date: 09/08/1993
• Status: Expired due to Term

• Current Assignee: Ajinomoto Co., Inc.
• Original Assignee: Ajinomoto Co., Inc.
• Inventors: Tsuji, Takashi, Morinaga, Yoshihiro, Ohsumi, Koji, Ohishi, Kazuo
• Primary Examiner(s): Raymond, Richard L.
• Application Number:
  US08/613,005
• Time in Patent Office: 746 Days
• Field of Search: 514/523, 514/646
• US Class Current: 514/646
• CPC Class Codes: C07C 205/35 having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• CPC Class Codes: C07C 205/37 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 217/80 having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
• CPC Class Codes: C07C 217/84 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 255/43 the carbon skeleton being further substituted by singly-bound oxygen atoms

Abstract

A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R¹, R² and R³, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.

Claims

1. A method for treating cancer in a patient comprising the step of administering a carcinosatically effective amount of a stilbene derivative of formula (I) or a pharmaceutically acceptable acid adition salt thereof:

##STR16## wherein R¹, R² and R³, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms;

X represents a hydrogen atom or a nitrile group;

Y represents an alkyloxy group having 1 to 3 carbon atoms or an alkyl group having 1 to 6 carbon atoms.

2. The method of claim 1, wherein R¹, R² and R³ are each a methyl group.

3. The method of claim 1, wherein X is a hydrogen atom.

4. The method of claim 1, wherein X is a nitrile group.

5. The method of claim 1, wherein Y is a methoxy group.

6. The method of claim 1, wherein the method comprises administering from 1 to 9000 mg/day of the stilbene derivative or a pharmaceutically acceptable acid addition salt thereof.