Method and device for precise release of an antimicrobial agent

• US 5,733,270 A
• Filed: 06/07/1995
• Issued: 03/31/1998
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Balteau, Patrick, Peluso, F., Lo, Ying-Cheng, Ling, Michael T. K., Woo, Lecon
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/474,839
• Time in Patent Office: 1,028 Days
• Field of Search: 604/82, 604/890.1, 604/4, 604/7, 604/19, 604/27, 604/56, 604/57, 604/84, 604/92, 604/257, 604/262, 604/265, 604/403, 604/408, 604/85, 604/326, 604/283, 604/905
• US Class Current: 604/326
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 39/162 with antiseptic agent incorporated within the connector
• CPC Class Codes: Y10S 604/905 Aseptic connectors or couplings, e.g. frangible, piercable

Abstract

An improved system and method for providing sterile connections. To this end, a device is provided comprising a body, a chamber defined, at least in part, by a portion of the body, the chamber including an interior having a solid sterilizing agent that can sublimate at ambient conditions, and a member that defines., in part, the chamber and is so constructed and arranged to allow the solid sterilizing agent to release in a rate controlled manner through the member.

Claims

1. A device comprising:

a body member;

a chamber defined, at least in part, by a portion of the body member, the chamber including an interior having a solid sterilizing component that sublimes at ambient conditions to provide a sterilizing gas in the interior; and

a controlled release member that defines, in part, the chamber and is so constructed and arranged to allow the sterilizing gas to pass in a rate controlled manner from the chamber through the controlled release member to the body member.

2. The device of claim 1 wherein the controlled release member is porous.

3. The device of claim 1 wherein the solid sterilizing component is iodine.

4. The device of claim 1 including means for coupling the device to another device.

5. The device of claim 1 including a fluid flow path through the device, the sterilizing gas contacting at least portions of the fluid flow path after it passes through the controlled release member.

6. The device of claim 1 including means for coupling the device to another device having a second fluid flow path and causing the fluid flow path and second fluid flow path to be in fluid communication.

7. A medical device comprising:

a body member including a fluid flow pathway therethrough;

a chamber member defining an interior, portions of the body member defining the chamber member, the chamber member including a controlled release member;

a solid sterilizing compound located within the interior that sublimes at ambient conditions to provide a sterilizing gas in the interior; and

the controlled release member being so constructed and arranged to allow at least some of the sterilizing gas to pass through the controlled release member and contact at least portions of the fluid flow pathway.

8. The device of claim 7 wherein the controlled release member is porous.

9. The device of claim 7 wherein the solid sterilizing component is iodine.

10. A system for coupling two flow pathways together comprising:

a first member including a first fluid flow pathway;

a second member including a second fluid flow pathway therethrough and a chamber member defining an interior, portions of the body defining the chamber, the chamber also being defined, in part, by a controlled release member, a solid sterilizing compound that sublimes at ambient conditions in the chamber providing a sterilizing gas in the interior, and the controlled release member is so constructed and arranged to allow at least some of the sterilizing gas to pass through the controlled release member and contact at least portions of the fluid flow pathway; and

means for removably coupling the first and second members together so that the first and second fluid flow pathways are in fluid communication.

11. The system of claim 10 wherein the controlled release member is porous.

12. The system of claim 10 wherein the solid sterilizing compound is iodine.

13. A method for performing peritoneal dialysis comprising the steps of implanting in the patient a catheter that includes at an end thereof a device comprising:

a body member including a fluid flow pathway therethrough;

a chamber member defining an interior, the chamber being defined, in part, by a controlled release member;

a solid sterilizing compound located within the chamber that sublimes at ambient conditions to provide a sterilizing gas in the interior; and

the controlled release member being so constructed and arranged to allow at least some of the sterilizing gas to pass through the controlled release member and contact at least portions of the fluid flow pathway.

14. The method of claim 13 wherein the solid sterilizing compound is a halogen.