System and method for modulating the output of an implantable medical device in response to circadian variations
First Claim
1. A rate-responsive pacemaker for delivering pacing pulses to a patient, the pacing pulses defined by a plurality of parameters including a first parameter and a second parameter, the plurality of parameters characterizing the rate, strength, form or similar attribute of the pulses, the pacemaker allowing for transitioning of at least two of the parameters in response to an onset of a stage in the patient'"'"'s circadian rhythm, the pacemaker comprising:
- pulse generating means for delivering the pacing pulses to the patient;
determining means for determining the onset of the stage in the patient'"'"'s circadian rhythm and for transmitting the determination; and
processing means, coupled to the determining means and coupled to the pulse generating means, for receiving the determination transmitted from the determining means and, in response, for transitioning a first value of the first parameter to a second value of the first parameter by a first transfer curve and for transitioning a first value of the second parameter to a second value of the second parameter by a second transfer curve, and for transmitting to the pulse generating means the second value of the first parameter, the second value of the second parameter and any intervening values of the first parameter and the second parameter produced during transitioning by the processing means; and
wherein the pulse generating means can respond to the transmission from the processing means by changing the pacing pulses delivered to the patient.
1 Assignment
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Accused Products
Abstract
An implantable cardiac pacemaker is provided for delivering pacing pulses to a patient, where the pacing pulses are defined by at least two parameters. The pacemaker allows for transitioning of the two parameters from first values to second values in response to the patient'"'"'s circadian rhythms, such as in response to the beginning and ending of a sleep cycle. Also provided is an implantable pacemaker for delivering pacing pulses to a patient where the pacing pulses are defined by at least one parameter. The pacemaker allows for selective transitioning of the parameter from a first value to a second value in response to the patient'"'"'s circadian rhythms.
76 Citations
49 Claims
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1. A rate-responsive pacemaker for delivering pacing pulses to a patient, the pacing pulses defined by a plurality of parameters including a first parameter and a second parameter, the plurality of parameters characterizing the rate, strength, form or similar attribute of the pulses, the pacemaker allowing for transitioning of at least two of the parameters in response to an onset of a stage in the patient'"'"'s circadian rhythm, the pacemaker comprising:
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pulse generating means for delivering the pacing pulses to the patient; determining means for determining the onset of the stage in the patient'"'"'s circadian rhythm and for transmitting the determination; and processing means, coupled to the determining means and coupled to the pulse generating means, for receiving the determination transmitted from the determining means and, in response, for transitioning a first value of the first parameter to a second value of the first parameter by a first transfer curve and for transitioning a first value of the second parameter to a second value of the second parameter by a second transfer curve, and for transmitting to the pulse generating means the second value of the first parameter, the second value of the second parameter and any intervening values of the first parameter and the second parameter produced during transitioning by the processing means; and wherein the pulse generating means can respond to the transmission from the processing means by changing the pacing pulses delivered to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A rate-responsive pacemaker for delivering pacing pulses to a patient, the pacing pulses defined by at least one parameter characterizing the rate, strength, form or similar attribute of the pulses, the pacemaker allowing for selective transitioning of the parameter from a first value to a second value in response to an onset of a stage in the patient'"'"'s circadian rhythm, the pacemaker comprising:
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pulse generating means for delivering the pacing pulses to the patient; determining means for determining an onset of a stage in the patient'"'"'s circadian rhythm and for transmitting the determination; and processing means, coupled to the determining means and coupled to the pulse generating means, for receiving the determination transmitted from the determining means and, in response, for transitioning the first value of the parameter to a second value of the parameter by a selectable transfer curve, and for transmitting to the pulse generating means the second value of the first parameter and any intervening values of the parameter produced during transitioning by the processing means; and wherein the processing means can set the selectable transfer curve to either a first transfer curve or a second transfer curve; and wherein the pulse generating means can respond to the transmission from the processing means by changing the pacing pulses delivered to the patient. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. An implantable medical device for delivering an output to a patient, the output defined by a plurality of parameters including a first parameter and a second parameter, the plurality of parameters characterizing the rate, strength, form or similar attribute of the output, the implantable medical device allowing for transitioning of at least two of the parameters in response to an onset of a stage in the patient'"'"'s circadian rhythm, the implantable medical device comprising:
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output generating means for delivering the output to the patient; determining means for determining the onset of the stage in the patient'"'"'s circadian rhythm and for transmitting the determination; and processing means, coupled to the determining means and coupled to the output generating means, for receiving the determination transmitted from the determining means and, in response, for transitioning a first value of the first parameter to a second value of the first parameter by a first transfer curve and for transitioning a first value of the second parameter to a second value of the second parameter by a second transfer curve, and for transmitting to the output generating means the second value of the first parameter, the second value of the second parameter and any intervening values of the first parameter and the second parameter produced during transitioning by the processing means; and wherein the output generating means can respond to the transmission from the processing means by changing the output delivered to the patient. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. An implantable medical device for delivering an output to a patient, the output defined by at least one parameter characterizing the rate, strength, form or similar attribute of the output, the implantable medical device allowing for selective transitioning of the parameter from a first value to a second value in response to an onset of a stage in the patient'"'"'s circadian rhythm, the implantable medical device comprising:
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output generating means for delivering the output to the patient; determining means for determining an onset of a stage in the patient'"'"'s circadian rhythm and for transmitting the determination; and processing means, coupled to the determining means and coupled to the output generating means, for receiving the determination transmitted from the determining means and, in response, for transitioning the first value of the parameter to a second value of the parameter by a selectable transfer curve, and for transmitting to the output generating means the second value of the first parameter and any intervening values of the parameter produced during transitioning by the processing means; and wherein the processing means can set the selectable transfer curve to either a first transfer curve or a second transfer curve; and wherein the output generating means can respond to the transmission from the processing means by changing the output delivered to the patient. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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Specification