Ported tissue implant systems and methods of using same
First Claim
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1. A method for implanting cells into a host tissue comprising the steps of:
- providing an implant assembly for holding cells including wall means having an interior surface defining a chamber for holding cells for implantation and exterior surface defining an interface with the host tissue, the wall means having a pore size sufficient to isolate the implanted cells from the immune response of the host tissue and having a metabolic transit value sufficient to sustain viability of implanted cells during ischemia, the exterior surface having a conformation which allows growth of vascular structures by the host tissue close to but not substantially into the interface, the implant assembly including a port;
adding cells into the chamber of the implant assembly through the port; and
implanting the implant assembly and port within a host.
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Abstract
A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
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Citations
16 Claims
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1. A method for implanting cells into a host tissue comprising the steps of:
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providing an implant assembly for holding cells including wall means having an interior surface defining a chamber for holding cells for implantation and exterior surface defining an interface with the host tissue, the wall means having a pore size sufficient to isolate the implanted cells from the immune response of the host tissue and having a metabolic transit value sufficient to sustain viability of implanted cells during ischemia, the exterior surface having a conformation which allows growth of vascular structures by the host tissue close to but not substantially into the interface, the implant assembly including a port; adding cells into the chamber of the implant assembly through the port; and implanting the implant assembly and port within a host. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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3. A method for implanting cells into a host tissue comprising the steps of:
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providing an implant assembly for holding cells including wall means having an interior surface defining a chamber for holding cells for implantation and exterior surface defining an interface with the host tissue, the wall means having a pore size sufficient to isolate the implanted cells from the immune response of the host tissue and having a metabolic transit value sufficient to sustain viability of implanted cells during ischemia, the exterior surface having a conformation which allows growth of vascular structures by the host tissue close to but not substantially into the exterior surface, the implant assembly including a port; implanting the implant assembly and port within a host; and accessing the port and adding cells to the chamber of the implant assembly through the port after the implant assembly has been implanted.
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15. A method for implanting cells into a host tissue comprising the steps of:
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providing a plurality of implant assemblies for holding cells, each implant assembly including wall means for forming a porous boundary between the host tissue and the implanted cells in the assembly, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response, the assembly including a tube; adding cells to an interior of the implant assembly through the tube; and coupling at least two tubes of the plurality of implant assemblies together with mechanical means. - View Dependent Claims (16)
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Specification