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Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars

  • US 5,733,509 A
  • Filed: 04/17/1996
  • Issued: 03/31/1998
  • Est. Priority Date: 04/17/1996
  • Status: Expired due to Fees
First Claim
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1. A system for synthesizing a plurality of oligonucleotides at a plurality of locations on a substrate, the plurality of locations arranged as a plurality of rows on the substrate, the system comprising:

  • a plurality of dispensing bars each having a respective plurality of dispensing heads arranged along a respective axis, each of the plurality of dispensing bars operative to selectively deposit from the plurality of dispensing heads a volume of a respective one of a plurality of nucleotide bases in any of a plurality of locations along a respective row;

    a positioning mechanism which positions the substrate with respect to the plurality of dispensing bars; and

    a controller which controls the plurality of dispensing bars the plurality of dispensing heads and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.

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