Method of EII using a water insoluble particulate agent

• US 5,733,525 A
• Filed: 03/31/1997
• Issued: 03/31/1998
• Est. Priority Date: 01/03/1992
• Status: Expired due to Fees

• Current Assignee: Nycomed Imaging AS (GE Healthcare Technologies, Inc.)
• Original Assignee: Nycomed Imaging AS (GE Healthcare Technologies, Inc.)
• Inventors: Klaveness, Jo
• Primary Examiner(s): Hollinden, Gary E.
• Application Number:
  US08/828,530
• Time in Patent Office: 365 Days
• Field of Search: 424/9.31, 424/9.32, 424/9.322, 424/9.45, 424/9.454, 424/9.455, 424/9.52, 424/450, 424/9.37, 424/9.321, 423/328, 436/173, 128/653.4, 128/654
• US Class Current: 424/9.31
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61K 49/0002 General or multifunctional contrast agents, e.g. chelated agents
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

The invention relates to a method of electrical impedance imaging of a human or animal subject which method comprises parenterally administering to the subject an EII contrast agent and generating an electrical impedance image of at least part of said subject. The contrast agent may be optionally dissolved or dispersed in a physiologically tolerable liquid carrier medium. The contrast agent is capable on dispersion in water of yielding a fluid having an electrical impedance different to that of water and being a water-insoluble particulate material.

Claims

1. A method of electrical impedance imaging of a human or animal subject which method comprises parenterally administering to said subject an EII contrast agent, optionally dissolved or dispersed in a physiologically tolerable liquid carrier medium and generating an electrical impedance image of at least part of said subject, said contrast agent being capable on dispersion in water of yielding a fluid having an electrical impedance different to that of water and being a water-insoluble particulate material.

2. A method as claimed in claim 1 wherein said contrast agent comprises ferromagnetic, ferrimagnetic or superparamagnetic particles.

3. A method as claimed in claim 1 wherein said contrast agent comprises metallic particles.

4. A method as claimed in claim 1 wherein said contrast agent comprises particles of a non-metallic electrical conductor.

5. A method as claimed in claim 1 wherein said contrast agent comprises a gas entrapping agent.