Enteral formulation designed for optimized wound healing

• US 5,733,884 A
• Filed: 11/07/1995
• Issued: 03/31/1998
• Est. Priority Date: 11/07/1995
• Status: Expired due to Fees

• Current Assignee: Nestec SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Barbul, Adrian, Bebenek, Lisa Stewart, Lin, Paul, Twyman, Diana, Mark, David A., Trimbo, Susan
• Primary Examiner(s): Tsang, Cecilia J.
• Assistant Examiner(s): Mohamed, Abdel A.
• Application Number:
  US08/554,475
• Time in Patent Office: 875 Days
• Field of Search: 514/21.2, 514/23, 514/54, 514/558, 514/560, 514/565, 514/943, 426/72, 426/607, 426/656, 426/658, 424/439
• US Class Current: 514/5.5
• CPC Class Codes: A23G 3/368 containing vitamins, antibiotics
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/0606 Arginine
• CPC Class Codes: A23V 2250/064 Proline
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1842 Lecithin
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/1944 Medium-chain triglycerides
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A23V 2250/70 Vitamins
• CPC Class Codes: A23V 2250/702 Vitamin A
• CPC Class Codes: A23V 2250/704 Vitamin B
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A23V 2250/71 Vitamin D
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/01 : Hydrolysed proteins; Derivatives thereof

Abstract

The present invention provides an enteral nutritional formulation that meets the nutrient requirements of patients with wounds. The present invention meets the unique nutrient needs of the acute or chronic patient that are generated due to tissue repair and healing requirements of wounds. To this end, in an embodiment, the present invention provides a method for providing nutritional support to a patient with an acute or chronic wound comprising the step of administering a therapeutically effective amount of composition comprising a protein source including an arginine source and a proline source in the ratio by weight of approximately 1:0.5 to about 4:1. The composition may also include a carbohydrate source, a lipid source including an appropriate n6:n3 ratio, and at least the U.S. RDA for vitamins and minerals provided in an amount of formula supplying 1000 kcal, with vitamin A, beta-carotene, vitamin C, vitamin E, thiamine, pyridoxine, biotin and zinc being supplied in amounts above the U.S. RDAs.

Claims

1. A method for providing nutritional support to a patient with an acute or chronic wound comprising the step of administering a therapeutically effective amount of a composition comprising:

a protein source comprising an arginine source in an amount of at least 2% of the total calories in the composition and a proline source in an amount of at least 2% of the total calories in the composition;

a lipid source; and

a carbohydrate source.

2. The method of claim 1 wherein the protein source comprises approximately 18% to about 35% of the total calories of the composition.

3. The method of claim 1 wherein the arginine source and the proline source are present in a ratio by weight of approximately 1:

0.5 to about 4;

1.

4. The method of claim 1 wherein the arginine source is present in an amount of at least 3.0% of the total calories of the composition.

5. The method of claim 1 wherein the proline source is present in an amount of at least 3.0% of the total calories of the composition.

6. The method of claim 1 wherein the arginine source comprises approximately 2.0% to about 6.0% of the total calories in the composition.

7. The method of claim 1 wherein the proline source comprises approximately 2.0% to about 4.0% of the total calories in the composition.

8. A method for promoting optimal collagen synthesis in acute or chronic wound patients comprising administering to the patient a composition having a protein source comprising a therapeutically effective amount of an arginine source and a proline source, the arginine source and proline source present in a ratio by weight of approximately 1:

0.5 to about 4;

1.

9. The method of claim 8 wherein the composition further comprises at least 100% of the U.S. RDA for vitamin A, vitamin C, beta-carotene, vitamin E, thiamin, pyridoxine, biotin and zinc.

10. The method of claim 8 wherein the arginine source comprises approximately 2.0% to about 6.0% of the total calories in the composition.

11. The method of claim 8 wherein the proline source comprises approximately 2.0% to about 4.0% of the total calories of the composition.

12. The method of claim 8 wherein the protein source comprises approximately 18% to about 35% of the total calories of the composition.

13. The method of claim 8 wherein the composition has a caloric density ranging from about 1.0 to 1.5 kcal/ml.

14. The method of claim 8 wherein the composition further comprises a lipid source and a carbohydrate source.

15. The method of claim 14 wherein the lipid source comprises a source of medium chain triglycerides, a source of omega-3 fatty acids and a source of omega-6 fatty acids.

16. The method of claim 14 wherein the lipid source comprises an omega-6 fatty acid to an omega-3 fatty acid ratio of approximately 5:

1.

17. A method for providing nutritional support to an acute or chronic wound patient with delayed wound healing comprising the step of administering a therapeutically effective amount of a composition comprising:

a protein source including an arginine source and a proline source, the arginine source and the proline source present in a ratio by weight of approximately 1;

0.5 to about 4;

1.

18. The method of claim 17 wherein the proline source is in an amount of approximately 5.0 to about 10.0 g/1000 kcal of the composition and the arginine source is in an amount of approximately 5.0 to about 15.0 g/1000 kcal of the composition.

19. The method of claim 17 wherein the composition is administered enterally.

20. The method of claim 17 wherein the composition is administered parenterally.