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Nucleic acid ligand inhibitors of human neutrophil elastase

  • US 5,734,034 A
  • Filed: 05/16/1995
  • Issued: 03/31/1998
  • Est. Priority Date: 06/11/1990
  • Status: Expired due to Fees
First Claim
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1. A nucleic acid ligand to elastase identified according to a method comprising the steps of:

  • a) contacting a candidate mixture of nucleic acids with elastase, wherein nucleic acids having an increased affinity to elastase relative to the candidate mixture may be partitioned from the remainder of the candidate mixture;

    b) partitioning the increased affinity nucleic acids from the remainder of the candidate mixture; and

    c) amplifying the increased affinity nucleic acids to yield a ligand-enriched mixture of nucleic acids, whereby a nucleic acid ligand to elastase may be identified.

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