Method and apparatus for scanning and evaluating matter

• US 5,735,276 A
• Filed: 03/21/1995
• Issued: 04/07/1998
• Est. Priority Date: 03/21/1995
• Status: Expired due to Term

• Current Assignee: Jerome H. Lemelson
• Original Assignee: Jerome H. Lemelson
• Inventors: Lemelson, Jerome
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/407,690
• Time in Patent Office: 1,113 Days
• Field of Search: 128/653.1, 128/664, 128/665, 128/633, 606/2, 606/10-12, 356/346, 250/458.1, 250/461.1, 250/461.2, 378/44, 378/45, 378/62, 378/64, 378/65, 348/68, 348/77, 348/164
• US Class Current: 600/407
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2017/00066 intensity
• CPC Class Codes: A61B 2018/00904 Automatic detection of target tissue
• CPC Class Codes: A61B 2018/20351 Scanning mechanisms
• CPC Class Codes: A61B 2018/20361 with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 34/70 Manipulators specially adapted for use in surgery
• CPC Class Codes: G01N 15/1468 with spatial resolution of the texture or inner structure of the particle

Abstract

A system and method for analyzing matter by computer analysis of electrical signals generated by sensing radiation reflected from matter (i.e. tissue, cells, liquid, gaseous or solid particles in a liquid or gas) and/or generated due to fluorescence. In one embodiment, a short pulse of laser radiation is directed at matter also scanned by an electro-optical scanning means to generate image signals. Fluorescent radiation and reflected radiation generating image signals, generate respective variable electrical signals which are computer processed and analyzed to detect and determine the chemical and/or biological composition of the matter. A television camera scans the matter and generates video signals for computer processing and analysis. Simultaneously or sequentially, pulsed laser energy is directed against plural locations of scanned matter, wherein each of such pulses generates a short duration of fluorescent energy in different select portions of the matter under analysis. Fluorescing light is photoelectrically detected generating variable electrical signals for each portion of fluorescing matter, which signals are computer processed and analyzed along with signals output by the television camera to provide information used to intelligibly indicate: (a) composition of such matter, (b) presence of one or more chemical and/or biological agents in such matter, (c) whether the matter is defective or diseased or, (d) a combination of such indications. The liquid may be any body fluid. Manipulators are provided to move the TV camera, lasers, sensors and treatment lasers and/or surgical instruments.

Claims

1. A method of electro-optically scanning tissue comprising the steps of:

(a) generating a first beam of radiation;

(b) scanning said tissue with said first beam of radiation, whereby said beam moves relative to said tissue, to cause said tissue to fluoresce;

(c) photoelectrically detecting said fluorescence and generating first variable electrical signals at a position to receive both reflected and fluorescent radiation;

(d) digitizing said first variable electrical signals and generating first digital code signals;

(e) spectrally analyzing said first digital code signals with a computer and generating second code signals; and

(f) employing said second code signals to intelligibly indicate the condition of said tissue.

2. The method of claim 1 wherein step (f) further comprises determining if the tissue is diseased.

3. The method of claim 1 wherein step (f) further comprises determining if the tissue is malignant.

4. The method of claim 1 wherein step (f) further comprises determining if the tissue is cancerous or precancerous.

5. The method of claim 1 further comprising the step of generating time code signals during scanning and employing said time code signals to indicate the location of a malignant condition in the first select tissue scan.

6. The method of claim 1 further comprising the step of generating time code signals during scanning and employing said time code signals to indicate the size of a malignant tumor condition in the first select tissue scan.

7. The method of claim 1 further comprising the step of generating time code signals during scanning and employing said time code signals to indicate the size and location of a malignant condition in the first select tissue scan.

8. The method of claim 1 further comprising the step of generating time code signals during scanning and employing said time code signals to indicate the size and location of a plurality of malignant tumor conditions in the first select tissue scan.

9. The method of claim 1 further comprising the step of employing the code signals generated in step (e) to control a process.

10. The method of claim 1 further comprising the step of employing the code signals generated in step (e) to control a machine.

11. The method of claim 1 further comprising the step of employing the code signals generated in step (f) to indicate the presence of a disease.

12. The method of claim 1 further comprising the step of employing the code signals generated in step (f) to indicate a disease wherein said disease is a tumor.

13. The method of claim 1 further comprising the step of employing the code signals generated in step (f) to indicate a disease wherein said disease is a cancer.

14. The method of claim 1 further comprising the step of employing the code signals generated in step (f) to indicate a disease wherein said disease is a cancerous tissue.

15. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam, whereby said beam moves relative to said tissue, to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter at a position to receive both reflected and fluorescent radiation and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter.

16. The method of claim 15 wherein said body matter is a body fluid.

18. The method of claim 15 wherein said body matter is blood.

19. The method of claim 15 wherein said method is performed in vivo.

20. The method of claim 15 wherein said method is performed in vitro.

21. The method of claim 15 wherein step (e) further comprises the step of quantizing said component.

22. The method of claim 15 wherein step (e) further comprises the step of quantizing a plurality of select contents of said matter.

23. The method of claim 15 wherein step (a) further comprises generating a beam of laser radiation of a predetermined wavelength.

24. The method of claim 15 wherein step (a) further comprises generating a beam of laser radiation of a predetermined frequency.

25. The method of claim 15 wherein step (a) further comprises:

(f) generating a beam of laser radiation having a wavelength adjusted over a predetermined range.

28. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range during a select time interval.

29. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range while the beam of laser radiation is scanning tissue.

30. The method of claim 25 wherein step (f) further comprises comprising controllably varying the wavelength of the beam of laser radiation over said predetermined range while the beam is scanning a select location of tissue.

32. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range while the laser beam is at a select tumor of the tissue.

33. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range while the beam is at a select organ.

34. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range while the beam is at a select area of tissue.

35. The method of claim 25 wherein step (f) further comprises controllably varying the wavelength of the beam of laser radiation over said predetermined range during a plurality of select time intervals.

38. The method of claim 15 wherein step (c) further comprises detecting a range of wavelengths of said fluorescent radiation.

39. The method of claim 15 wherein step (c) further comprises detecting a plurality of ranges of wavelengths of said fluorescent radiation.

40. The method of claim 15 wherein step (c) further comprises detecting a range of wavelengths and intensity of said fluorescent radiation.

41. The method of claim 15 wherein step (c) further comprises detecting a range of wavelengths and rate of change of intensity of said fluorescent radiation.

42. The method of claim 15 wherein step (c) further comprises detecting a range of wavelengths and rate of decay of intensity of said fluorescent radiation.

43. The method of claim 15 wherein step (c) further includes analyzing the chemical contents of said body matter.

44. The method of claim 15 wherein step (c) further includes analyzing the biological contents of said body matter.

45. The method of claim 15 wherein said body matter is body tissue.

46. The method of claim 15 wherein said body matter is a body fluid.

47. The method of claim 15 wherein said body matter is blood.

48. The method of claim 15 wherein step (b) further comprises scanning cellular matter.

49. The method of claim 15 wherein step (b) further comprises scanning cells.

51. The method of claim 15 wherein step (a) further comprises providing a tunable laser for generating a beam of laser radiation and tuning said tunable laser to change the wavelength thereof.

52. The method of claim 15 wherein step (a) further comprises providing a tunable laser for generating said beam of laser radiation and controllably tuning said tunable laser to change the frequency thereof.

75. The method of claim 15 wherein step (a) further comprises the step of generating said beam of laser radiation of a predetermined intensity.

76. The method of claim 15 wherein step (a) further comprises the step of generating said beam of laser radiation of a first predetermined frequency to scan a first region and of a second predetermined frequency to scan a second region.

77. The method of claim 15 wherein step (a) further comprises the step of:

(f) generating said beam of laser radiation having a wavelength adjusted over a predetermined intensity.

78. The method of claim 15 wherein step (a) further comprises the step of generating said beam of laser radiation of a first predetermined intensity to scan a first region and of a second predetermined intensity to scan a second region.

79. The method of claim 15 wherein step (a) further comprises the step of generating said beam of laser radiation of a first predetermined wavelength to scan a first region and of a second predetermined wavelength to scan a second region.

17. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, said body fluid being lymph fluid.

26. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (d) further comprising operating the computer in an open-loop manner.

27. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (d) further comprising operating the computer in a closed-loop manner.

31. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (f) further comprises comprising controllably varying the wavelength of the beam of laser radiation over said predetermined range while the beam is at a select pixel of tissue.

36. A method for automatically testing body matter of a living being to determine its contents comprising the step of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising moving the body matter relative to the beam of radiation.

37. The method of claim 36 wherein the step of moving the body matter further comprises providing a body fluid in motion relative to said radiation beam to effect scanning.

50. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising scanning proteins.

53. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising impinging the body matter with the beam of radiation whereby fluorescent radiation is generated by the body matter and is modulated with information representing the composition of said body matter.

54. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising impinging the body matter with the beam of radiation whereby fluorescent radiation is generated by the body matter and is modulated with information representing the biological composition of said body matter.

55. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising impinging the body matter with the beam of radiation whereby fluorescent radiation is generated by the body matter and is modulated with information representing the chemical composition of said body matter.

56. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising impinging the body matter with the beam of radiation whereby fluorescent radiation is generated by the body matter and is modulated with information to identify the cancerous nature of the body matter.

57. A method for automatically testing body matter of a living being to determine its contents comprising the steps of:

(a) generating a beam of radiation;

(b) scanning a first amount of body matter with said beam to cause said first amount of body matter to fluoresce;

(c) photoelectrically detecting the fluorescent radiation generated by said first amount of body matter and generating first electrical signals;

(d) computer processing and analyzing said first electrical signals and generating first code signals; and

(e) employing said first code signals to intelligibly indicate at least one component of said first amount of body matter, step (b) further comprising impinging the body matter with the beam of radiation whereby fluorescent radiation is generated by the body matter and is modulated with information to identify the non-cancerous nature of the body matter.

58. A method for performing an operation on the body of a living being comprising the steps of:

(a) directing first penetrating radiation against a select portion of a living being, which select portion contains select tissue to be operated on,

(b) after said first radiation has intersected said select tissue and has become modulated with information relating to said select tissue, receiving said radiation with a sensing means and transducing same to electrical signals,

(c) computer processing and analyzing said electrical signals and generating first control signals,

(d) applying said first control signals to control the operation of a power-operated treatment means in a manner to cause said treatment means to perform a first operation on a select portion of said select tissue as determined by the information contained in said first modulated electrical signals, wherein said first operation is operable to effect a first degree of change in said select portion of said select tissue,

(e) thereafter generating and causing an additional amount of said first radiation to penetrate said select tissue and to become modulated in intersecting said select tissue with information defining said select tissue with the change therein effected by said first amount of said treatment radiation,

(f) receiving said additional amount of said first radiation after it is so modulated and transducing same to second electrical signals,

(g) computer processing and analyzing said second electrical signals and generating second control signals,

(h) applying said second control signals to further control the operation of said power operated treatment means to cause it to effect an additional operation on a further select portion of said select tissue.

59. A method in accordance with claim 58 wherein said power operated treatment means comprises a radiation beam generating means and said method further comprises the step of controlling the operation of the radiation beam generating means according to said control signals to selectively irradiate and treat said select portions of said select tissue.

60. A method in accordance with claim 59 wherein said radiation beam treatment means is operated to destroy said select portions of said tissue of said living being.

61. A method in accordance with claim 59 wherein said radiation beam defining said treatment means is operated to change physical characteristics of said select portions of said select tissue.

62. A method in accordance with claim 59 wherein said radiation beam defining said treatment means is operated to change biological characteristics of said select portions of said select tissue.

63. A method in accordance with claim 58 wherein said power operated treatment means comprises a motor driven surgical device and said method further comprises the steps of controlling the surgical device to surgically operate on said select portions of said select tissue under the control of said control signals generated in computer processing and analyzing the electrical signals generated by computer processing and analyzing said electrical signals.

64. A method for operating on tissue deep within a body of a living being comprising the steps of:

(a) providing a high energy radiation beam generating means, such as an ion beam generator preferably generating a beam of particles of sufficient intensity to operate on living tissue,

(b) disposing a living being to be operated on at a select location on a support which is supported adjacent to said beam generating means;

(c) operating said radiation beam generating means in a first mode to generate and direct a beam of charged particles at a select location of the body of said living being and to intersect select body surface tissue of said living being at a select angle thereto and penetrate beneath said body surface tissue by traveling therethrough along a select path,

(d) tuning said radiation beam to a first frequency to cause it to release its particle energy at a select first location within the body of said living being in a manner to irradiate and destroy first tissue at said first location.

65. The method of claim 64 further comprising the step of:

(e) effecting computer-controlled relative movement between said radiation beam and the body of said living being to cause select tissue at the location at which said beam penetrates the living beings body to predeterminately change while simultaneously computer controlling the frequency of said beam in a manner to predeterminately vary same in synchronization with the movement of said beam with respect to the body of said living being whereby the beam intersects and releases its energy within said select tissue adjacent the tissue destroyed by said beam at said first select location.

66. A method in accordance with claim 64 wherein said computer controlled relative movement between said beam and the body of said living being is effected by computer controlling operation of at least one motor operable to variably drive the support for said living being while said living being is immovably retained on said support.

67. A method in accordance with claim 64 wherein said computer controlled relative movement between said beam and the body of said living being is effected by computer controlling the operation of at least one motor operable to selectively control operation of a plurality of motors with each other, which plurality of motors are operable to variably drive the support to said living being in a plurality of directions.

68. A method in accordance with claim 65 wherein said relative movement between the body of said living being and said radiation beam is effected by predeterminately defecting said beam of radiation at a fixed location under computer control in synchronization with the computer controlled variation in the frequency of said beam.

69. A method for treating a malignant growth in a living being comprising the steps of:

(a) initially scanning a select portion of the body containing the malignancy;

(b) generating scanning signals representative of an image of the scanned region which represent radiation which is either reflected or fluoresced from the scanned region;

(c) analyzing the signals representing the image;

(d) scanning said region a second time with a beam of laser radiation by computer controlling a tunable laser to vary one of frequency and wavelength of the beam of laser radiation during scanning;

(e) detecting the radiation fluorescing from the region due to scanning by said beam of laser radiation; and

(f) computer analyzing the variable spectral signals to determine the nature of the malignancy.

70. The method of claim 69 wherein the analyzing step further comprises determining one of the type of malignancy, the stage of the malignancy, quantitative data relating to the malignancy.

71. The method of claim 70 wherein the data obtained in the step of determining characteristics of the malignancy further include operating a treatment apparatus.

72. The method of claim 71 wherein the treatment apparatus further includes delivering a drug to the region to be treated.

73. The method of claim 71 further comprising the step of generating a laser beam for treating the malignancy.

74. The method of claim 69 further comprising the step of operating a surgical instrument to treat the malignancy responsive to step (f).

80. A method of electro-optically scanning tissue comprising the steps of:

(a) generating a first beam of radiation;

(b) scanning said tissue with said first beam of radiation to cause said tissue to fluoresce;

(c) photoelectrically detecting said fluorescence and generating first variable electrical signals;

(d) digitizing said first variable electrical signals and generating first digital code signals;

(e) spectrally analyzing said first digital code signals with a computer and generating second code signals; and

(f) employing said second code signals to intelligibly indicate the condition of said tissue;

step (b) further comprising performing a raster scan.

81. A method of electro-optically scanning tissue comprising the steps of:

(a) generating a first beam of radiation;

(b) scanning said tissue with said first beam of radiation to cause said tissue to fluoresce;

(c) photoelectrically detecting said fluorescence and generating first variable electrical signals;

(d) digitizing said first variable electrical signals and generating first digital code signals;

(e) spectrally analyzing said first digital code signals with a computer and generating second code signals;

(f) employing said second code signals to intelligibly indicate the condition of said tissue;

and step (b) further comprises performing a spiral scan.

82. A method for treating living matter comprising the steps of:

generating a beam of radiation;

selecting at least one of the intensity, wavelength, frequency of the beam according to information indicating a given condition of said living matter; and

scanning a portion of said matter according to information indicating a location of said given condition.

83. A method of scanning and treating tissue comprising the steps of:

A method of electro-optically scanning tissue comprising the steps of;

(a) generating a first beam of radiation;

(b) scanning said tissue with said first beam of radiation to cause said tissue to fluoresce;

(c) photoelectrically detecting said fluorescence and generating first variable electrical signals;

(d) digitizing said first variable electrical signals and generating first digital code signals;

(e) spectrally analyzing said first digital code signal with a computer and generating second code signals; and

(f) employing said second code signals to intelligibly indicate the condition of said tissue;

(g) directing first penetrating radiation against a select portion of a living being, which select portion contains select tissue to be operated on,

(h) after said first radiation has intersected said select tissue and has become modulated with information relating to said select tissue, receiving said radiation with a sensing means and transducing same to electrical signals,

(i) computer processing and analyzing said electrical signals and generating first control signals,

(j) applying said first control signals to control the operation of a power-operated treatment means in a manner to cause said treatment means to perform a first operation on a select portion of said select tissue as determined by the information contained in said first modulated electrical signals, wherein said first operation is operable to effect a first degree of change in said select portion of said select tissue,

(k) thereafter generating and causing an additional amount of said first radiation to penetrate said select tissue and to become modulated in intersecting said select tissue with information defining said select tissue with the change therein effected by said first amount of said treatment radiation,

(l) receiving said additional amount of said first radiation after it is so modulated and transducing same to second electrical signals,

(m) computer processing and analyzing said second electrical signals and generating second control signals,

(n) applying said second control signals to further control the operation of said power operated treatment means to cause it to effect an additional operation on a further select portion of said select tissue.