NES-1 polypeptides, DNA, and related molecules and methods
First Claim
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1. A substantially pure Normal Epithelial Specific (NES1) polypeptide, said NES1 polypeptide having the amino acid sequence shown in FIG. 10 (SEQ ID NO:
- 1).
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Abstract
The expression and purification of normal epithelial specific polypeptide (NES1) which is expressed in normal cells, but not in radiation transformed cells, are described. Both the DNA sequence encoding the NES1 and the corresponding amino acid sequence are disclosed. Also, disclosed are methods for carcinoma detection and treatment using the NES1 as well as methods of identifying compounds modulating the expression and activity of NES1.
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2 Claims
- 1. A substantially pure Normal Epithelial Specific (NES1) polypeptide, said NES1 polypeptide having the amino acid sequence shown in FIG. 10 (SEQ ID NO:
Specification
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Current AssigneeNew England Medical Center Hospitals, Inc.
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Original AssigneeNew England Medical Center Hospitals, Inc.
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InventorsBand, Vimla
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Primary Examiner(s)Wax, Robert A.
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Assistant Examiner(s)Nashed, Nashaat T.
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Application NumberUS08/467,155Time in Patent Office1,036 DaysField of Search435/219, 435/23, 435/6, 435/212, 435/240.1, 435/224, 435/226, 536/23.5, 536/24.31, 530/350US Class Current435/219CPC Class CodesC12N 9/6424 Serine endopeptidases (3.4.21)
