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Cyclic peptide surface feature mimics of endothelin

  • US 5,736,509 A
  • Filed: 11/10/1994
  • Issued: 04/07/1998
  • Est. Priority Date: 12/14/1990
  • Status: Expired due to Fees
First Claim
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1. A substantially pure peptide of formula (III):

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    space="preserve" listing-type="equation">cyclo(X.sup.1 -X.sup.2 -X.sup.3 -X.sup.4 -L-Trp) (III)or a pharmaceutically acceptable salt thereof, wherein;

    X1 is D-Leu, D-Val, D-lle, D-Ala, Gly, Aib, D-Nva, D-Nle or D-Alle;

    X2 is L-Val, L-lle, L-Leu, L-Ala, L-Gln, L-Gly, Aib, L-Nva, L-Nlle or L-Alle;

    X3 is D-Pro, D-Hyp, D-Ala, D-Val, D-lle, Gly, Aib, D-Nva, D-Nle or D-Alle; and

    X4 is L-Asp, L-Glu, L-Tyr, L-Ser, L-Thr, L-Cys(O3 H) or L-Pen(O3 H).

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