Method for separation of matter from suspension

• US 5,738,792 A
• Filed: 09/06/1994
• Issued: 04/14/1998
• Est. Priority Date: 03/21/1984
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Schoendorfer, Donald W.
• Primary Examiner(s): SPEAR JR, FRANK
• Application Number:
  US08/302,223
• Time in Patent Office: 1,316 Days
• Field of Search: 210/651, 210/741, 210/650, 210/321.63, 210/321.68, 210/321.87, 210/391, 210/404, 210/784
• US Class Current: 210/651
• CPC Class Codes: A61M 1/265 inducing Taylor vortices
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: B01D 2313/48 Mechanisms for switching between regular separation operations and washing
• CPC Class Codes: B01D 2313/903 Integrated control or detection device
• CPC Class Codes: B01D 2315/02 Rotation or turning
• CPC Class Codes: B01D 2321/02 Forward flushing
• CPC Class Codes: B01D 61/025 Reverse osmosis; Hyperfiltration
• CPC Class Codes: B01D 63/062 with membranes on a surface of a support tube
• CPC Class Codes: B01D 63/16 Rotary, reciprocated or vibrated modules
• CPC Class Codes: B01D 65/02 Membrane cleaning or sterilisation ; Membrane regeneration

Abstract

A process for filtration of matter from a liquid suspension through a membrane uses a rotor within a concentric shell rotating with a surface velocity which, together with the rotor-shell gap and suspension viscosity, establishes vigorous vortex cells about the rotor. At least one of the rotor and shell surfaces include a filter membrane. Tangential velocity components at the membrane surface constantly sweep the membrane surface to limit cell deposition tendencies while constantly replenishing the medium to be filtered. The vortex cells are established along the length of the membrane despite the constant extraction of filtrate and the resultant change in physical characteristics of the suspension.

Claims

1. A method for filtering filtrate from a cellular suspension comprising the steps of

feeding the cellular suspension into a space defined between an inner surface of a stationary housing body and an outer surface of a rotor rotatable within the stationary housing body, the inner surface of the stationary housing body carrying a microporous filter membrane,

rotating the rotor at a rate selected to establish annular vortices about the rotor substantially filling the space,

passing filtrate through the microporous filter membrane to the inner surface of the housing body, and

collecting filtrate passing through the microporous filter membrane via a conduit in the stationary housing body that communicates with the inner surface of the stationary housing body.

20. A method according to claim 1 or 18 or 19

wherein the step of rotating the rotor includes rotating the rotor free of a filter membrane.

2. A method for filtering a cellular suspension comprising the steps of

feeding the cellular suspension into a space defined between an inner surface of a stationary housing body and an outer surface of a rotor rotatable within the stationary housing body, one of the inner surface and the outer surface carrying a microporous filter membrane,

rotating the rotor at a rate selected to establish a vortex action comprising annular vortices within and substantially filling the space,

collecting filtrate passing through the microporous filter membrane,

sensing transmembrane pressure,

maintaining a desired filtrate extraction rate through the microporous filter membrane, and

reducing the extraction rate of filtrate while maintaining the vortex action when transmembrane pressure rises above a calculated value, to thereby clean the microporous filter membrane by action of the annular vortices.

3. A method according to claim 2

wherein, in the step of feeding the cellular suspension, the cellular suspension is whole blood,

wherein, in the step of collecting filtrate, the filtrate is plasma, and

wherein, in the step of reducing the extraction rate of filtrate, the calculated value is no greater than about 165 mm Hg.

4. A method according to claim 2

wherein the step of reducing the filtrate extraction rate includes increasing fluid flow in the space when the transmembrane pressure exceeds the calculated value, thereby causing the desired reduction in filtrate flow rate.

5. A method according to claim 2

wherein, the microporous filter membrane is on the inner surface of the stationary housing body so that, during the step of rotating the rotor, the microporous filter membrane is held stationary on the inner surface.

6. A method according to claim 2

wherein, the microporous filter membrane is on the outer surface of the rotor so that the step of rotating the rotor rotates the microporous filter membrane.

7. A method according to claim 2

and further comprising the step of temporarily introducing rinsing fluid from a source into the space while simultaneously temporarily reducing the input of suspension into the space while maintaining annular vortices in the space.

8. A blood constituent filtering method comprising the steps of

introducing blood constituent into a gap area disposed between relatively rotating generally cylindrical surfaces, at least one of which includes a blood constituent filtering membrane to filter out a blood constituent and for passing a filtrate therethrough,

rotating one of the generally cylindrical surfaces relative to the other one of the generally cylindrical surfaces to produce Taylor vortices within the gap area, which entrain blood constituents in a sweeping action that passes adjacent to the filtering membrane,

detecting the onset of filter membrane pore clogging by cellular blood constituents, and

controlling at least one operating parameter to cause cleaning of the clogged pores by the sweeping action of blood constituents entrained in the Taylor vortices.

9. A method according to claim 8

wherein the step of detecting comprises monitoring fluid pressure at an inlet to the gap area, and

wherein the step of controlling comprises reducing flux of filtrate in response to monitored pressure.

10. A method according to claim 9

wherein the step of monitoring detects the transmembrane fluid pressure across the filter membrane, and

wherein the step of controlling reduces plasma flux passing through the filter membrane in response to transmembrane fluid pressure in excess of about 165 mm Hg.

11. A method according to claim 8

wherein the step of rotating includes rotating a spinner member within a stationary housing, the stationary housing having an interior wall carrying a filter membrane that is disposed radially outwardly of the rotating spinner member.

12. A method according to claim 8

wherein the step of rotating includes rotating a spinner member within a stationary housing, the spinner member having an exterior wall carrying a filter membrane that is rotated relative to the stationary housing.

13. A method according to claim 8

and further including the step of temporarily introducing ringing fluid from a source into the gap area while simultaneously temporarily reducing input of blood constituents into the gap area while maintaining the Taylor vortices.

14. A method for filtering a suspension of cellular components comprising the steps of

passing the suspension between a rotating spinner and an outer shell, one of the rotating spinner and the outer shell carrying a filter membrane,

establishing a vortex action comprising a plurality of annular vortices in the suspension about the spinner and adjacent the membrane,

sensing the transmembrane pressure while maintaining a desired extraction rate of filtrate through the membrane,

comparing the transmembrane pressure to a transmembrane pressure value calculated to achieve extraction of filtrate with desired membrane efficiency and without substantial damage to the cellular components;

and

reducing the extraction rate of filtrate while maintaining the vortex action to clean the membrane when the transmembrane pressure rises above the calculated value.

15. A method according to claim 14

wherein the step of reducing the filtrate extraction rate includes the step of increasing fluid flow past the rotating spinner and the outer shell when the transmembrane pressure extends the calculated value, thereby causing the reduction in filtrate flow rate.

16. A method according to claim 14

and further including the step of maintaining the filtrate extraction rate substantially constant when the transmembrane pressure is below the calculated value.

17. A method according to claim 14

and further including the step of introducing a rinsing fluid between the rotating spinner end the outer shell while the filtrate extraction rate is reduced to assist in cleaning the membrane.

18. A method for filtering filtrate from a suspension having a cellular component subject to trauma when stressed comprising the steps of

feeding the suspension into a space defined between an inner surface of a stationary housing body and an outer surface of a rotor rotatable within the stationary housing body, the inner surface of the stationary housing body carrying a microporous filter membrane,

rotating the rotor at a rate selected to establish annular vortices, which substantially fill the space about the rotor, without causing substantial trauma to the cellular component,

passing filtrate through the microporous filter membrane to the inner surface of the housing body, and

collecting filtrate passing through the microporous filter membrane via a conduit in the stationary housing body that communicates with the inner surface of the stationary housing body.

19. A method for filtering filtrate from a suspension containing at least one cellular blood component comprising the steps of

feeding the suspension into a space defined between an inner surface of a stationary housing body and an outer surface of a rotor rotatable within the stationary housing body, the inner surface of the stationary housing body carrying a microporous filter membrane,

rotating the rotor at a rate selected to establish annular vortices, which substantially fill the space about the rotor, without causing substantial damage to the cellular blood component,

passing filtrate through the microporous filter membrane to the inner surface of the housing body, and

collecting filtrate passing through the microporous filter membrane via a conduit in the stationary housing body that communicates with the inner surface of the stationary housing body.