Biocompatible coated article
First Claim
1. A method of coating a porous membrane with an polylactone-polysiloxane-polyactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
5 Assignments
0 Petitions
Accused Products
Abstract
The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.
35 Citations
25 Claims
- 1. A method of coating a porous membrane with an polylactone-polysiloxane-polyactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
- 8. A method of coating a porous membrane with an polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.02 to 0.35.
-
18. A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a concentration of the copolymer, said concentration imparting to the membrane, when dry, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
- 19. A method of coating a porous membrane with a polylactone-polysiloxane-polylactone triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a concentration of the copolymer, said rate and concentration being such that, when dry, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
Specification